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MetabolomicsControl of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001658 | MetabolomicsWorkbench
MetabolomicsInhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle
Not available
ORGANISM(S): Mus musculus 
ST000513 | MetabolomicsWorkbench
TranscriptomicsInhibition of the mitochondrial TCA cycle by monofluoroacetate in Arabidopsis thaliana
Plant mitochondria signal to the nucleus leading to altered transcription of nuclear genes by a process called mitochondrial retrograde regulation (MRR). MRR is implicated in metabolic homeostasis and responses to stress conditions. Transcriptional consequences on nuclear gene expression of mitochon...
ORGANISM(S): Arabidopsis thaliana 
2013-01-01 | E-GEOD-29268 | biostudies-arrayexpress
ProteomicsMetabolic bypass partially rescues S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism has been associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced plur...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042436 | Pride
S-nitrosylation Alzheimer’s disease Mitochondrial metabolism Tca cycle inhibition 
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been strongly implicated in synucleinopathies, including Parkinson’s disease (PD) and Lewy body dementia (LBD), but the underlying molecular basis is not fully understood. Here, using human induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036797 | Pride
S-nitrosylation Alpha-synuclein Tca cycle Mitochondrial dysfunction 
MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
GenomicsABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
PRJNA1240100 | ENA
GenomicsComplex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells
Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells
PRJNA1467718 | ENA
MetabolomicsTargeted metabolomics analysis by LC-MS/MS for BMDCs infected with VSV
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-18 | MTBLS12438 | MetaboLights
TranscriptomicsComplex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells
In many cancers, stably elevated MYC levels drive persistent and concerted activation of cell growth promoting anabolic programs and cell cycle in ways distinct from normal cells. Therefore, synthetic-lethal targeting of MYC-reprogrammed pathways offers selective strategies against MYChigh tumors. T...
ORGANISM(S): Homo sapiens 
2026-05-19 | GSE331349 | GEO
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