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TranscriptomicsMyocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection
Aims. Serial invasive endomyocardial biopsies (EMB) remain the gold standard for acute cellular rejection (ACR) diagnosis. However histological grading has several limitations. We aimed to explore the value of myocardial Gene Expression Profiling (GEP) for diagnosing and identifying predictive bioma...
ORGANISM(S): Homo sapiens 
2017-03-07 | E-MTAB-5136 | biostudies-arrayexpress
TranscriptomicsInnate molecular and cellular signature in the skin preceding long-lasting T cell responses after electroporated DNA vaccination
DNA vaccines delivered with electroporation have shown promising results in pre-clinical models and are evaluated in clinical trials. Here, we aim to characterize early mechanisms occuring in the skin after intradermal injection and electroporation of the auxoGTUmultiSIV DNA vaccine in non-human pri...
ORGANISM(S): Macaca fascicularis 
2020-04-10 | E-MTAB-8973 | biostudies-arrayexpress
TranscriptomicsStage-specific IFN-induced and IFN gene expression reveals convergence of type I and type II IFN and highlights their role in both acute and chronic phases of pathogenic SIV infection
Interferons (IFNs) play a major role in controlling viral infections including HIV/SIV infections. Persistent up-regulation of interferon stimulated genes (ISGs) is associated with chronic immune activation and progression in SIV/HIV infections, but the respective contribution of different IFNs is u...
ORGANISM(S): Macaca fascicularis 
2017-10-30 | E-MTAB-6068 | biostudies-arrayexpress
TranscriptomicsTranscriptional comparison of cynomolgus macaques (Macaca fascicularis) following infection with Lassa or Lujo viruses
Microarray analysis of PBMC from cynomolgus macaques collected longitudinally over the course of infection with Lassa-Josiah, Lassa-Z132, Lassa-SorombaR, or Lujo viruses (n=3 animals/infection condition). 3 macaques from each group were infected intramuscularly with 10^4 PFU of Lassa-Josiah, Lassa-Z...
ORGANISM(S): Macaca fascicularis 
2014-08-29 | E-GEOD-49838 | biostudies-arrayexpress
TranscriptomicsMolecular and cellular dynamics in the skin, the lymph nodes and the blood of the immune response to intradermal injection of Modified Vaccinia Ankara vaccine
New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early in...
ORGANISM(S): Macaca fascicularis 
2017-12-29 | E-MTAB-5907 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic analysis of acute host responses during 2009 pandemic H1N1 influenza infection in mouse, macaque, and swine (swine dataset)
Background: The 2009 pandemic H1N1 influenza virus emerged in swine and quickly became a major global health threat. In mouse, non-human primate, and swine infection models, the pH1N1 virus efficiently replicates in the lung and induces pro-inflammatory host responses; however, whether similar or di...
ORGANISM(S): Sus scrofa 
2012-09-12 | E-GEOD-40847 | biostudies-arrayexpress
TranscriptomicsVaccine inoculation route modulates early immunity and consequently antigen-specific immune response
Vaccination is one of the most efficient public healthcare measures to fight infectious diseases. Nevertheless, the immune mechanisms induced in vivo by vaccination are still unclear. The route of administration, an important vaccination parameter, can substantially modify the quality of the respons...
ORGANISM(S): Macaca fascicularis 
2021-05-17 | E-MTAB-10309 | biostudies-arrayexpress
TranscriptomicsSeminal plasma exposures strengthen vaccine responses in the female reproductive tract mucosae
HIV-1 sexual transmission occurs mainly via mucosal semen exposures. In the female reproductive tract (FRT), seminal plasma (SP) induces physiological modifications, including inflammation. An effective HIV-1 vaccine should elicit mucosal immunity. However, modifications of vaccine responses by the ...
ORGANISM(S): Macaca fascicularis 
2019-02-12 | E-MTAB-7639 | biostudies-arrayexpress
TranscriptomicsModified Vaccinia virus Ankara vector induces specific cellular and humoral responses in the female reproductive tract, the main HIV portal of entry
The female reproductive tract is one of the major mucosal invasion site of HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the female reproductive tract after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a...
ORGANISM(S): Macaca fascicularis 
2017-06-09 | E-MTAB-5663 | biostudies-arrayexpress
TranscriptomicsNK cell immune responses differ after prime and boost vaccination
A better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified vaccinia virus Ankara using cynomolgus macaques as a model. Mass cytom...
ORGANISM(S): Macaca fascicularis 
2019-02-19 | E-MTAB-7697 | biostudies-arrayexpress
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