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UnknownCatch bond models may explain how force amplifies TCR signaling and antigen discrimination.
Not available
S-EPMC10163261 | biostudies-literature
UnknownEvolution by innovation as a driving force to improve TCR-T therapies.
Not available
S-EPMC10552759 | biostudies-literature
UnknownTCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding.
Not available
S-EPMC6708305 | biostudies-literature
GenomicsParsing digital or analogue TCR performance through piconewton forces
Parsing digital or analogue TCR performance through piconewton forces
PRJNA1003535 | ENA
TranscriptomicsThe T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces
Obesity has become a major public health crisis given its rampant growth and association with an increased risk for cancer. Cancer patients who present with obesity tend to have increased tumor burden and decreased T-cell function, yet it remains unclear how obesity compromises T-cell mediated immun...
ORGANISM(S): Mus musculus 
2026-06-20 | GSE335537 | GEO
UnknownMechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.
Not available
S-EPMC6408234 | biostudies-literature
TranscriptomicsAtomistic TCR-ligand interactions instruct memory T-cell differentiation and crossreactivity
While memory T-cells provide protective immunity against specific pathogens, their post-encounter differentiation into central (TCM) and/or effector (TEM) subpopulations remains enigmatic. We thus explored the CD8 T-cell receptor (TCR) repertoire of 242 murine TCR clonotypes directed against an im...
ORGANISM(S): Mus musculus 
2026-02-18 | GSE302680 | GEO
ProteomicsMechano-ID: proximity labeling of mechanically active receptors and cells
A major challenge in the field of mechanobiology relates to the lack of methods that enable identification of mechanically active cells and force transmitting receptors for subsequent biochemical analysis. For example, potent T cell activation requires the transmission of biophysical forces between ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-26 | PXD066067 | Pride
Tcr force T cell receptor Proximity labeling Dna tension probes 
TranscriptomicsParsing digital or analogue TCR performance through piconewton forces
T lymphocytes leverage T-cell receptor (TCR) recognition of aberrant peptides bound to major histocompatibility complex molecules (pMHCs) on altered cells to protect the mammalian host from infectious pathogens and cancerous transformations. While adaptive immunity requires efficient TCR performance...
ORGANISM(S): Mus musculus 
2024-08-21 | GSE240414 | GEO
UnknownAccumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.
Not available
S-EPMC4123688 | biostudies-literature
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