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TranscriptomicsCheckpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor infiltrating CD8+ T cells
Coinhibitory receptor blockade is a promising strategy to boost immunity against a variety of human cancers. However, many patients still do not benefit from this treatment, and responders often experience immune-related toxicities. These issues highlight the need for improved understanding of check...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-58722 | biostudies-arrayexpress
TranscriptomicsAngiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model
TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture. AKR/J mice were exposed to Cigarette Smoke (CS) for a period of two months. Some animals received a treatment of Losartan (.6gr/L) orally while exposed (CS Los). These two groups are to be compare...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-33561 | biostudies-arrayexpress
UnknownImpact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
Not available
S-EPMC8410470 | biostudies-literature
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Not available
S-EPMC3079639 | biostudies-literature
UnknownImpact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial.
Not available
S-EPMC8319138 | biostudies-literature
TranscriptomicsDifferential gene expression in wild-type versus Yaa mutant mouse spleen cells
T cells from many patients with systemic lupus erythematosus are hypoproliferative in response to TCR ligation. This defect is mediated, at least in part, through down regulation of the TCR zeta chain. Investigation of this phenomenon in lupus-prone mice revealed that the hypoproliferative T cell ph...
ORGANISM(S): Mus musculus 
2009-12-15 | E-GEOD-9287 | biostudies-arrayexpress
UnknownPrevention of Colon Cancer Recurrence From Minimal Residual Disease: Computer Optimized Dose Schedules of Intermittent Apoptotic Adjuvant Therapy.
Not available
S-EPMC8462567 | biostudies-literature
UnknownTargeting CD8+ T-cell tolerance for cancer immunotherapy.
Not available
S-EPMC4215555 | biostudies-literature
UnknownCigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
Not available
S-EPMC5896544 | biostudies-literature
TranscriptomicsGene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke
Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement. This dataset includes 4 wild-type mice exposed...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-33512 | biostudies-arrayexpress
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