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TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
TranscriptomicsExpression data by telomere elongation in xenograft.
Telomere erosion causes cell mortality, suggesting that longer telomeres allow greater number of cell division. In telomerase-positive human cancer cells, however, telomeres are often kept shorter than the surrounding normal tissues. Recently, we have shown that telomere elongation in cancer cells r...
ORGANISM(S): Homo sapiens 
2015-02-05 | E-GEOD-56177 | biostudies-arrayexpress
TranscriptomicsExpression data by telomere elongation in vivo (xenograft)
Limitless reproductive potential is one of the hallmarks of cancer cells1. This ability is accomplished by maintaining telomeres, which erosion otherwise causes cellular senescence or death. Human cancer cells often maintain shorter telomeres than do cells in surrounding normal tissues2-5. While mos...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-41559 | biostudies-arrayexpress
TranscriptomicsExpression data by telomere elongation
Limitless reproductive potential is one of the hallmarks of cancer cells1. This ability is accomplished by maintaining telomeres, which erosion otherwise causes cellular senescence or death. Human cancer cells often maintain shorter telomeres than do cells in surrounding normal tissues2-5. While mos...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-36649 | biostudies-arrayexpress
UnknownThe TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.
Not available
S-EPMC8867601 | biostudies-literature
UnknownActivation of a LTR-retrotransposon by telomere erosion.
Not available
S-EPMC307637 | biostudies-literature
GenomicsReduced representation bisulfite sequencing from G0 & G4/G5 CMP
Differential hyper- and hypo-methylation regions in G0 versus G4/G5 CMP The goal of this study is to evaluate changes in CpG methylation profilings of telomere dysfunctional common myeloid progenitor cells (CMP) as compared to their wild type controls Genomic DNA was extracted from sorted CMP popula...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-62392 | biostudies-arrayexpress
UnknownTelomere Length Measurement by Molecular Combing.
Not available
S-EPMC7308456 | biostudies-literature
UnknownTelomerase insufficiency induced telomere erosion accumulation in successive generations in dyskeratosis congenita family.
Not available
S-EPMC6625126 | biostudies-literature
ProteomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1
Telomere erosion contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive human cells to loss of telomere integrity, and uncovered a previously unannotated...
ORGANISM(S): Homo sapiens (Human) 
2021-03-04 | PXD022128 | Pride
C16orf72 Crispr-cas9 Genome-wide screen Telomere erosion P53 Telomerase inhibitor 
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