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ProteomicsTGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression
Extracellular vesicles (EVs) are important mediators of intercellular communications in tumor microenvironment (TME). EV-mediated TGF-β signaling in the TME facilitates tumor metastasis and immune evasion by transferring TGF-β ligands and regulators to recipient cells. The mechanisms of how TGF-β af...
ORGANISM(S): Homo sapiens (Human) 
2024-12-28 | PXD052799 | Pride
Extracellular vesicles Tgf-β Rab27b 
ProteomicsExtracellular vesicles from TGF-β-activated cancer-associated fibroblasts remodel the tumor microenvironment through EV surface-associated proteins
Cancer-associated fibroblasts (CAFs) are a major stromal cell type within the tumor microenvironment (TME). Transforming growth factor-β (TGF-β) is a key cytokine in the TME that activates CAFs, which alters their ability to remodel the extracellular matrix (ECM) and changes their secretome profile....
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061656 | Pride
Cancer-associated fibroblast Tgf-β Tsg6 Cd8+ t cells Extracellular vesicles Ev surface-associated proteins 
ProteomicscircTBRII(3-6) acts as assembly platform for IGF2BP3 protein and TBRI mRNA to enhance breast cancer cell plasticity
Transforming growth factor (TGF)-β signaling is a key driver to induce epithelial-to-mesenchymal transition (EMT), a process that enhances cancer cell plasticity and metastatic potential. However, the role of circular RNAs (circRNAs) in TGF-β signaling remains largely unexplored. Here, we identify c...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061218 | Pride
Insulin-like growth factor 2 mrna binding protein 3 Circtbrii(3-6) Epithelial-to-mesenchymal transition Transforming growth factor (tgf)-β 
UnknownThe TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding.
Not available
S-SCDT-10_1038-S44319-024-00323-2 | biostudies-other
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