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TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
TranscriptomicsGene array analysis of human CD34+ hematopoietic cells exposed during 24h to HOXB4 or HOXC4 homeoproteins
At the molecular level, the mechanisms of action of Hox genes during hematopoiesis remain elusive. Although reports have described the implication of Hox genes in some molecular pathways in mice, the targets of HOX proteins in human hematopoietic cells are mostly unidentified. Since HOXB4 and HOXC4 ...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-24379 | biostudies-arrayexpress
TranscriptomicsCharacterisation of LAP/LIP transcriptional signature in human hepatoma cells
BACKGROUND & AIMS: C/EBPbeta is involved in numerous process as carcinogenesis but its role is still not clear due to the existence of an active form (LAP) and an inhibitory form (LIP) of this transcription factor. The main goals of the present research were (i) the identification of genes inversely...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-15010 | biostudies-arrayexpress
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