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ProteomicsTenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties
The purpose of this project is to determine changes in proteins and signaling pathways in injured tendons of C57BL/6j and MRL/MpJ mice. The MRL.MpJ mice have been reported to have a strong repair ability compared to that of C57BL/6j mice. Identifying signaling pathways in MRL/MpJ tendons that are di...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-16 | PXD057712 | Pride
Tendon c57bl/6j Injury Mrl/mpj Achilles tendon 
TranscriptomicsAccelerated flexor tendon repair in superhealer mice reflects alterations in TGFB1 regulated expression programs linked to inflammatory, fibrosis and cell cycle control
Purpose: The goal of this study is to compare transcriptional profiles of flexor tendon healing in wild-type (WT, C57Bl/6J) to superhealer (MRL/MpJ) miceto gain insights in the biological drivers of the tendon injury response between the C57 and MRL mice. Methods: RNA was isolated from patially lace...
ORGANISM(S): Mus musculus 
2022-01-04 | GSE175912 | GEO
GenomicsAccelerated flexor tendon repair in superhealer mice reflects alterations in TGFB1 regulated expression programs linked to inflammatory, fibrosis and cell cycle control
Accelerated flexor tendon repair in superhealer mice reflects alterations in TGFB1 regulated expression programs linked to inflammatory, fibrosis and cell cycle control
PRJNA734292 | ENA
UnknownHedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.
Not available
S-EPMC9686894 | biostudies-literature
UnknownStructural and mechanical effects of in vivo fatigue damage induction on murine tendon.
Not available
S-EPMC3755359 | biostudies-literature
UnknownAltered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.
Not available
S-EPMC8863792 | biostudies-literature
UnknownSystemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.
Not available
S-EPMC4552471 | biostudies-literature
UnknownEffects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.
Not available
S-EPMC7708438 | biostudies-literature
TranscriptomicsTranscriptomic Analysis of Cellular Pathways during Healing of Flexor Tendons in Plasminogen Activator Inhibitor Type 1, Member 1 (PAI-1/Serpine1) Null Mice
Injuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Adhesions have been associated with PAI-1, a master suppressor of protease activity including matrix metalloproteinases (MMP). In the present study, we used next generation RNA sequen...
ORGANISM(S): Mus musculus 
2019-05-31 | GSE125026 | GEO
UnknownModulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.
Not available
S-EPMC6510478 | biostudies-literature
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