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UnknownPediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.
Not available
S-EPMC11444160 | biostudies-literature
ProteomicsExpansion of DUB functionality by alternative isoforms: USP35, a case study
Protein ubiquitylation is a dynamic post-translational modification that can be reversed by deubiquitylating enzymes (DUBs). It is unclear how the small number of ~100 DUBs present in mammalian cells regulates the thousands of different ubiquitylation events. Here we analysed annotated transcripts o...
ORGANISM(S): Homo sapiens (Human) 
2018-04-27 | PXD009286 | Pride
Endoplasmic reticulum Apoptosis Deubiquitinase Lipid droplets Ubiquitin signalling 
ProteomicsDiscovery and characterization of ZUFSP, a novel DUB class important for genome stability
Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and cataly...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008509 | Pride
Ubiquitin binding domain Deubiquitinase Dna damage 
UnknownA feasibility randomised controlled trial to evaluate the role of computed tomography in adults with atypical right iliac fossa pain.
Not available
S-EPMC6818076 | biostudies-literature
MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
UnknownFeasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma - protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial.
Not available
S-EPMC10414059 | biostudies-literature
UnknownA case-control and cohort study to determine the relationship between ethnic background and severe COVID-19.
Not available
S-EPMC7545271 | biostudies-literature
UnknownUsing a smartphone-based self-management platform to support medication adherence and clinical consultation in Parkinson's disease.
Not available
S-EPMC5460235 | biostudies-literature
UnknownPrespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).
Not available
S-EPMC4898313 | biostudies-literature
ProteomicsCouzens_Hippo_P103_VS1_BioID
Not available
2013-07-04 | MSV000078460 | MassIVE
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