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ProteomicsProteomic analysis after interference with TERC in bladder cancer cell line
Muscle-invasive bladder cancer is closely associated with the susceptibility to metastasis and poor prognosis. In recent years, numerous studies have revealed that certain long non-coding RNAs (lncRNAs) may be involved in malignant progression of tumors. Here, we identified a lncRNA, telomerase RNA ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD062013 | Pride
Human Bladder cancer Terc Lc-ms/ms 
TranscriptomicsKnockdown of TERC with siRNA in normal bone marrow stromal cells (BMSCs) recapitulates the defective BMSC phenotype in patients with telomere biology disorders
Dyskeratosis congenita (DC) is an inherited multi-system disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow failure, solid tumors, and other medical problems such as osteopenia. DC and telomere biology disorders (collect...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-GEOD-64023 | biostudies-arrayexpress
TranscriptomicsTelomeric DNA damage response activation mediates idiopathic pulmonary fibrosis caused by telomere dysfunction
Lungs from wild type and Terc KO mice, treated with DDR inhibitors
ORGANISM(S): Mus musculus 
2026-07-10 | E-MTAB-14908 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional manipulation of TERC reverses molecular hallmarks of telomere disease
The telomerase RNA component (TERC) is a critical determinant of cellular self renewal. Poly(A)-specific ribonuclease (PARN) is required for post-transcriptional maturation of TERC. PARN mutations lead to incomplete 3′ end processing and increased destruction of nascent TERC RNA transcripts, resul...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-81507 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of testis from wild type mice and mice lacking telomerase for three generations (G3-Terc), Ku86 or both telomerase and Ku86 to identify effectors of mammalian telomere dysfunction.
Transcriptome of murine testis from wild type mice and mice lacking telomerase for three generations (G3-Terc), Ku86 or both telomerase and Ku86.
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2498 | biostudies-arrayexpress
GenomicsATAC-Seq of wild type and Terc-/- ESCs
ATAC-Seq of wild type and Terc-/- ESCs
PRJNA764680 | ENA
TranscriptomicsGenome-wide analysis of telomerase-regulated genes in MLL-AF9 acute myeloid leukemia stem cells (LSCs)
Genome-wide transcriptional profiling of purified telomerase deficient (Terc-/-) and WT LSCs was performed in order to gain insights into the mechanisms underlying the susceptibilities of Terc-/- LSCs in vivo. Results provide important information on the response of LSCs to telomerase deficiency, su...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-63241 | biostudies-arrayexpress
GenomicsGenome-wide analysis of TERC occupancy in MRC5 fibroblast cells by ChIRP-seq
Genome-wide analysis of TERC occupancy in MRC5 fibroblast cells by ChIRP-seq
PRJNA761438 | ENA
GenomicsSingle-cell transcriptome analysis of Terc KO bone marrow and brain
Single-cell transcriptome analysis of Terc KO bone marrow and brain
PRJNA787494 | ENA
TranscriptomicsPost-transcriptional manipulation of TERC reverses molecular hallmarks of telomere disease
The telomerase RNA component (TERC) is a critical determinant of cellular self renewal. Poly(A)-specific ribonuclease (PARN) is required for post-transcriptional maturation of TERC. PARN mutations lead to incomplete 3′ end processing and increased destruction of nascent TERC RNA transcripts, resulti...
ORGANISM(S): Homo sapiens 
2016-08-02 | GSE81507 | GEO
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