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TranscriptomicsscRNAseq of hiPSC, iMeLC, hPGCLC aggregates and hEGCLC of CTL08A genotype
In this work, hEGCLC have been obtained for the first time from hPGCLC in defined and feeder-free conditions. To study transcriptional changes during the transition from a pluripotent stem cell state to a germ cell identity and back again, we profiled hiPSC, iMeLC, day6 hPGCLC aggregates and hEGCLC ...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15244 | biostudies-arrayexpress
GenomicsEMseq of hiPSC, iMeLC, hPGCLC and hEGCLC of CTL08A genotype
In this work, hEGCLC have been obtained for the first time from hPGCLC in defined and feeder-free conditions. To study epigenetic changes (in terms of DNA methylation) during the transition from a pluripotent stem cell state to a germ cell identity and back again, we profiled hiPSC, iMeLC, day 6 hPG...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15142 | biostudies-arrayexpress
ProteomicsGTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Copy number variations at 7q11.23 cause neurodevelopmental disorders with shared and opposite manifestations. Deletion leads to Williams-Beuren syndrome (WBS), while duplication causes 7q11.23 microduplication syndrome (7Dup). Converging evidence indicates GTF2I, from the 7q11.23 locus, is a key me...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD036770 | Pride
Sociability Organoids Neurodevelopment Autism Gtf2i Transcriptomics 
Transcriptomics7q11.23 dosage-dependent dysregulation in the human pluripotent state primes aberrant transcriptional programs in disease-relevant lineages
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63058 | biostudies-arrayexpress
GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [ChIP_seq]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-09 | E-GEOD-30972 | biostudies-arrayexpress
GenomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [ChIP-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76289 | biostudies-arrayexpress
TranscriptomicsPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network [RNA-Seq]
Malignant gliomas constitute one of the most significant areas of unmet medical need, due to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a c...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-76291 | biostudies-arrayexpress
UnknownOnce Upon a Time… an Atrial Myxoma: A Case Report of a Delayed Diagnosis.
Not available
S-EPMC12530714 | biostudies-literature
TranscriptomicsBulk RNA-seq of cerebral organoids investigating the role of CHD8 in cortical development
We used cerebral organoids generated from wildtype and CHD8 +/- human ES cells to study the effects of CHD8, one of the top ASD risk genes, on early cortical development. CHD8 +/- hESC were generated using the CRISPR/Cas9 system to create a deletion within the helicase domain. Cerebral organoids wer...
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-9933 | biostudies-arrayexpress
UnknownElements Characterising Multicomponent Interventions Used to Improve Disease Management Models and Clinical Pathways in Acute and Chronic Heart Failure: A Scoping Review.
Not available
S-EPMC10178532 | biostudies-literature
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