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TranscriptomicsExpression data from β-globin let7 HeLa tet off cells treated with doxycycline
We used microarray to determine the genes whose expression was changed at six hours after doxycycline treatment Cells were transfected with β-globin let7 wt constructs. Two-condition experiment; HeLa tet off cells overexpressed control vs HeLa tet off cells treated with doxycycline for six hours
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-66541 | biostudies-arrayexpress
no omics definedTranscription profiling of breast cancer cells with TET-OFF regulated ERb expression treated with estradiol or ICI, an estrogen receptor antagonist
Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERa and ERb-mediated gene regulation in T47D breast cancer cell line with TET-OFF regulated ERb expression.
ORGANISM(S): Homo sapiens 
2007-12-17 | E-MEXP-969 | biostudies-arrayexpress
TranscriptomicsRNA sequencing expression analysis of murine Tet-off MLL-AF9;NRAS acute myeloid leukemia cells over-expressing Id2 and upon MLL-AF9 withdrawal
We investigated the role of the transcriptional regulator Id2 in the context of MLL-rearranged acute myeloid leukemia (AML). Using an AML mouse model driven by tet-regulated MLL-AF9 co-expressed with oncogenic NRASG12D (Tet-off MLL-AF9), we demonstrated that MLL-AF9 regulates the E protein pathway b...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-68462 | biostudies-arrayexpress
TranscriptomicsHuman glioblastoma cells: Tet-on(mutant p53 R175H expression) vs Tet-off(p53-null)
TP53 R175H mutation is one of the most common mutations in human cancers and cancer cells with this mutation stably express R175H protein in the nucleus. To identify the synthetic lethal gene interacted with the R175H, we conducted the high throughput screening by using tetracyclin inducible R175H e...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-33362 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of control and EJC factor (EIF4A3, RBM8A, MAGOH) knockdowns in part with EIF4A3 rescue in HeLa Tet-Off cells
The exon junction complex is involved in gene expression regulation on multiple co- and post-transcriptional levels. We aimed to investigate in HeLa Tet-Off cells which gene expression alterations can be observed upon knockdown of core EJC factors (EIF4A3, RBM8A and MAGOH) or upon EIF4A3 knockdown a...
ORGANISM(S): Homo sapiens 
2022-05-06 | E-MTAB-10771 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of control and RNPS1 knockdown with or without RNPS1-RRM domain rescue in HeLa Tet-Off cells
RNPS1 is a splicing regulatory protein and a component of the ASAP/PSAP complex, which is associated with the exon junction complex and modulates alternative splicing. It was previously postulated that the isolated RRM domain of RNPS1 in complex with ASAP/PSAP is able to regulate certain alternative...
ORGANISM(S): Homo sapiens 
2022-06-22 | E-MTAB-10768 | biostudies-arrayexpress
UnknownComparison of GAL80ts and Tet-off GAL80 transgenes.
Not available
S-EPMC10080293 | biostudies-literature
GenomicsRNA-seq profiling of murine Tet-off MLL-AF9 NRAS acute myeloid leukemia at different timepoints upon doxycycline-induced MLL-AF9 down-regulation.
RNA-seq profiling of murine Tet-off MLL-AF9 NRAS acute myeloid leukemia at different timepoints upon doxycycline-induced MLL-AF9 down-regulation.
PRJNA423168 | ENA
UnknownRegulating the UAS/GAL4 system in adult Drosophila with Tet-off GAL80 transgenes.
Not available
S-EPMC5733373 | biostudies-literature
TranscriptomicsMCF7 tet-off cells treated or not with 80 ng/ml doxycycline for 12d
Tet-on and tet-off systems are among the most popular vector systems for inducible transgene expression in mammalian cells. In tet-regulated systems the expression of the transgene depends on the presence or absence of the antibiotic tetracycline or its derivative doxycycline, which are added to the...
ORGANISM(S): Homo sapiens 
2011-05-20 | GSE13926 | GEO
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