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TranscriptomicsTranscription profiling by array of Legionella pneumophila ppGpp knockout and relA over expression mutants.
Effect of ppGpp on transcript level after RelA overexpression (90 min). The cells are constructed in our lab. They are knock-out mutants in the production of ppGpp(guanosine tetraphosphate) of Legionella, complemented with an over-expression vector containing the relA gene to express the RelA prot...
ORGANISM(S): Legionella pneumophila 
2010-04-14 | E-MTAB-211 | biostudies-arrayexpress
ProteomicsTrinucleotide cap analogs with tetraphosphate modifications: interaction partners in HEK293F cell lysate
This dataset was acquired to identify human proteins binding to tetraphosphate mRNA cap analogs. Affinity resins were derivatized with tetraphosphate mRNA cap analogs or a trinucleotide cap control and affinity purification performed in HEK293F cell extracts. The pulled-down proteins were eluted us...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD053198 | Pride
Tetraphosphate Affinity purification Hek293f 5′ cap Mrna 
TranscriptomicsTranscription profiling by array of Legionella pneumophilaEfter RelA overexpression.
Effect of ppGpp on transcript level after RelA overexpression (45 min). The cells are constructed in our lab. They are knock-out mutants in the production of ppGpp(guanosine tetraphosphate) of Legionella, complemented with an over-expression vector containing the relA gene to express the RelA prot...
ORGANISM(S): Legionella pneumophila 
2010-04-13 | E-MTAB-222 | biostudies-arrayexpress
GenomicsThe diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
The diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
PRJNA1076844 | ENA
GenomicsAdenosine 5’-tetraphosphate and adenosine triphosphate signaling in THP-1 macrophages.
Adenosine 5’-tetraphosphate and adenosine triphosphate signaling in THP-1 macrophages.
PRJNA1137324 | ENA
UnknownAntiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds.
Not available
S-EPMC10895676 | biostudies-literature
TranscriptomicsThe diadenosine tetraphosphate hydrolase ApaH is crucial for Pseudomonas aeruginosa pathogenicity
The role of the intracellular signaling molecule diadenosine tetraphosphate (Ap4A) has not so far been investigated in Pseudomonas aeruginosa. To fill this gap, we performed RNA sequencing (RNA-seq) analysis to compare the transcriptome of the reference strain P. aeruginosa PAO1 and an isogenic dele...
ORGANISM(S): Pseudomonas aeruginosa 
2024-08-07 | GSE255863 | GEO
TranscriptomicsAdenosine 5’-tetraphosphate and adenosine triphosphate signaling in THP-1 macrophages.
The endogenous nucleotide adenosine 5’-tetraphosphate (Ap4) has emerged as a potent vasoconstrictor. Despite its structural similarity to the danger signal adenosine triphosphate (ATP), the immunomodulatory effects of Ap4 remain unclear. To gain a deeper insight into the biological processes underly...
ORGANISM(S): Homo sapiens 
2025-02-21 | GSE272546 | GEO
ProteomicsChemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However, their cellu...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-15 | PXD020740 | Pride
Photo-affinity labeling Proteomics Apna 
UnknownThe mysterious diadenosine tetraphosphate (AP4A).
Not available
S-EPMC10148737 | biostudies-literature
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