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TranscriptomicsBisphenol A Exposure and Multiple Sclerosis Risk
Bisphenol A Exposure and Multiple Sclerosis Risk Comparison of vehicle-treated vs. BPA-treated mouse testes tissue. Each comparison in technical and biological duplicate (Done twice: total 4 replicates)
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-45917 | biostudies-arrayexpress
TranscriptomicsThe transcriptional response of mouse uterus to estrogen is genetically regulated
The growth and development of the uterus in response to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous work from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 has led ...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-38800 | biostudies-arrayexpress
TranscriptomicsGene microarray analysis of mouse-brain endothelial cells exposure to Pertussis Toxin and B-oligomer
Pertussis Toxin (PTX) regulated inflammatory and angiogenesis-related transcripts in endothelial cells from mouse brain(MBEC). Of ~14,000 mouse genes tracked, 34 showed altered expression in response to PTX, and most of these changes were dependent on the ADP-ribosyltransferase activity of the S1 su...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-11288 | biostudies-arrayexpress
TranscriptomicsSperm miRNA expression data from male C57BL/6J, C57BL/6J-ChrY^SJL, and C57BL/6J-ChrY^RF
The prevalence of some autoimmune diseases (AID) is greater in females compared with males, notwithstanding that disease severity is often greater in males. The reason for this sexual dimorphism (SD) is unknown, but may reflect negative selection of Y chromosome (ChrY) bearing sperm during spermatog...
ORGANISM(S): Mus musculus 
2015-01-16 | E-GEOD-65047 | biostudies-arrayexpress
TranscriptomicsLymph node CD4+ T cell expression data from naM-CM-/ve female offspring of C57BL/6J and C57BL/6J-ChrY^SJL
The prevalence of some autoimmune diseases (AID) is greater in females compared with males, notwithstanding that disease severity is often greater in males. The reason for this sexual dimorphism (SD) is unknown, but may reflect negative selection of Y chromosome (ChrY) bearing sperm during spermatog...
ORGANISM(S): Mus musculus 
2015-01-16 | E-GEOD-65038 | biostudies-arrayexpress
TranscriptomicsLymph node CD4+ T cell and thioglycollate-elicited peritoneal macrophage expression data from naM-CM-/ve young and old SJL/J and SJL-ChrY^B10.S male mice
Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of ...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-47437 | biostudies-arrayexpress
TranscriptomicsLymph node CD4+ T cell miRNA expression data from naM-CM-/ve C57BL/6J and C57BL/6J-ChrY^SJL
Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of ...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-47439 | biostudies-arrayexpress
TranscriptomicsLymph node CD4+ T cell expression data from naïve C57BL/6J and C57BL/6J-ChrY^SJL
Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of ...
ORGANISM(S): Mus musculus 
2013-05-17 | E-GEOD-47024 | biostudies-arrayexpress
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