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TranscriptomicsMultifaceted maturation of monocyte-derived dendritic cells stimulated by intracellular bacteria
Background: It has been shown that intracellular pathogens hijack DC functions to evade immune defense mechanisms. In this study, we investigated the responses of human monocyte derived DCs to four intracellular bacteria, Tropheryma whipplei, Coxiella burnetii, Brucella abortus and Orientia tsutsuga...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
TranscriptomicsSex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm
Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profil...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-21065 | biostudies-arrayexpress
TranscriptomicsHost microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses
In this study, we performed a miRNA global profiling in human lung epithelial cells (A549) infected by two different subtypes of human influenza A viruses (H1N1 and H3N2). A549 cells were either mock-infected or infected at a multiplicity of infection (MOI) of 1 with H1N1 or H3N2 viruses, and total ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42003 | biostudies-arrayexpress
TranscriptomicsOrientia tsutsugamushi, the agent of scrub typhus, induces an inflammatory program in human macrophages
Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that mainly infects endothelial cells in vitro and in vivo. Evidence suggests that the interaction of O. tsutsugamushi with myeloid cells may play a pivotal role in O. tsutsugamushi infection. We showed here tha...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-38194 | biostudies-arrayexpress
TranscriptomicsInterferon-related transcriptional program is induced by chronic hepatitis E infection in kidney-transplant recipients
Background: Hepatitis E Virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients in Europe. Factors associated with the occurrence and persistence of chronic HEV infection remain largely unknown but chronic evolution seems to be the consequence of hostM-bM-^@M-^...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-36539 | biostudies-arrayexpress
TranscriptomicsCoxiella burnetii, the agent of Q fever, persists in adipocytes
Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cu...
ORGANISM(S): Mus musculus 
2014-05-25 | E-GEOD-46335 | biostudies-arrayexpress
TranscriptomicsGene expression signature-based screening identifies new broadly effective influenza antivirals
Classical antiviral therapy inhibit viral proteins and are subject to resistance. To counteract this emergence, alternative strategy has been developed that target cellular factors. We hypothesized that such approach could also be useful to identify broad antivirals. Influenza A virus was used as a ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-22319 | biostudies-arrayexpress
TranscriptomicsSevere preeclampsia: new blood circulating biomarkers
Background: Preeclampsia (PE) is a placental disease characterized by hypertension and proteinuria in pregnant women, which is associated with a high maternal and infantile morbidity. However, circulating biomarkers able to predict the prognosis of PE are lacking. Methods: Thirty-eight women were in...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-48424 | biostudies-arrayexpress
UnknownCritical role of segment-specific packaging signals in genetic reassortment of influenza A viruses.
Not available
S-EPMC3791739 | biostudies-literature
TranscriptomicsRegulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications
The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
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