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ProteomicsSIRT3 Deacetylates TFAM to Promote Mitochondrial Biogenesis
SIRT3 is a NAD+-dependent mitochondrial protein deacetylase participating in the regulation of central metabolism and mitochondrial proteostasis. SIRT3 is downregulated in clear cell renal cell carcinoma (ccRCC), a main type of renal cancers, but the function of SIRT3 in tumorigenesis and developmen...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD009110 | Pride
Proteomics Sirt3 Mitochondrial biogenesis Clear cell renal cancer Tfam acetylation 
UnknownAcetylation and phosphorylation of human TFAM regulate TFAM-DNA interactions via contrasting mechanisms.
Not available
S-EPMC5909435 | biostudies-literature
ProteomicsPhosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction
TFAM in-vitro phosphorylation by hPKAc and nonenzymatic acetylation by acetyl-CoA
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-04 | MSV000088788 | MassIVE
UnknownKnockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression.
Not available
S-EPMC7072172 | biostudies-literature
UnknownReduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart.
Not available
S-EPMC10250906 | biostudies-literature
UnknownGCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury.
Not available
S-EPMC9724393 | biostudies-literature
UnknownSIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM.
Not available
S-EPMC6315986 | biostudies-literature
GenomicsChIP-seq analysis of H3K27ac in K562 cells with shRNA-mediated depeltion of TFAM expression
The developing erythroid cells require highly coordinated gene expression and metabolism. By comparing the proteomic and transcriptomic changes in human hematopoietic stem/progenitor cells (HSPCs) and lineage-committed erythroid progenitors (ProEs), and uncover pathways related to mitochondrial biog...
ORGANISM(S): Homo sapiens 
2017-05-15 | GSE86864 | GEO
UnknownPhosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction.
Not available
S-EPMC9006650 | biostudies-literature
ProteomicsOxygen sensitive regulation of TFAM linking the von Hippel-Lindau cancer syndrome to impaired mitochondrial biogenesis
The major consumers of oxygen in the cell are mitochondria. Here we identified an oxygen-sensitive regulation of TFAM, a key activator of mitochondrial transcription and replication. TFAM is hydroxylated by EglN3 on proline 53/56 and subsequently bound by the tumor suppressor von Hippel Lindau (pVHL...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD022734 | Pride
Lc-ms/ms Tmt Mitocondria Hippel-lindau cancer syndrome Oxygen regulation 
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