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GenomicsFunctional link between TFIIB and Mediator
In this study, we generate genomic maps of Mediator, Pol II, TBP, TFIIH, TFIIA, TFIIB, TFIIE, TFIIF, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae and in a mutant for the Mediator essential subunit Med10
ORGANISM(S): Saccharomyces cerevisiae 
2017-01-24 | E-MTAB-4607 | biostudies-arrayexpress
GenomicsGenome wide TFIIB binding during postnatal and pressure-induced cardiac hypertrophy
Purpose: To identify the differential TFIIB bindingl patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjecetd to Transaortic coarctation or adult mice. The hearts were sent to Ac...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-56813 | biostudies-arrayexpress
ProteomicsProtein interaction network revealed by quantitative proteomic analysis elucidates TFIIB role in multiple aspects of the transcription cycle
Although TFIIB is widely regarded as an initiation factor, recent reports have implicated it in multiple aspects of eukaryotic transcription. To investigate the broader role of TFIIB in transcription, we performed quantitative proteomic analysis of yeast TFIIB. We purified two different populations ...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-05-24 | PXD041878 | Pride
Budding yeast Proteomic analyses Rna polymerase ii Tfiib Transcription 
TranscriptomicsComparative ChIP-chip analysis of general transcription factor TFIIB and negative cofactor NC2 in human B cells
A comparative ChIP-chip analysis of TFIIB and NC2 in human B cells reveals that basal core promoter architectures control the equilibrium between NC2 and preinitiation complexes. We conducted a comparative ChIP-chip and gene expression analysis of TFIIB in human B cells and analyze associated core p...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19562 | biostudies-arrayexpress
GenomicsTranscriptomic effects of caspase cleavage at TFIIB residue D207 during apoptosis and KSHV infection [TFIIB(D207A)]
Transcriptomic effects of caspase cleavage at TFIIB residue D207 during apoptosis and KSHV infection [TFIIB(D207A)]
PRJNA1053809 | ENA
GenomicsTFIIB
TFIIB
PRJNA1053806 | ENA
GenomicsTFIIB ChIP-seq for S. cerevisiae - Genome-wide generalized additive models
ChIP-seq experiment (IP and input control) for the general transcription factor TFIIB in S. cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
2016-12-22 | E-MTAB-4175 | biostudies-arrayexpress
ProteomicsCooperative clamp-mediated promoter recognition by poxviral RNA polymerase and its TBP/TFIIB-like partner
The recruitment of RNA polymerase (RNAP) to gene promoters is a critical step in gene expression. For RNAP II, this process is initiated by the TATA-box binding protein (TBP) and transcription factor IIB (TFIIB), with homologs of these TBP/TFIIB pairs found in all known multi-subunit RNAP systems. H...
ORGANISM(S): Vaccinia virus Homo sapiens (Human) 
2025-12-17 | PXD065561 | Pride
Vaccinia virus Clamp-loading Tbp/tfiib-like Cryo-electron microscopy Pre-initiation complex Non-canonical promoter recognition Transcription initiation 
GenomicsFunctional link between TFIIB and Mediator
Functional link between TFIIB and Mediator
PRJEB13355 | ENA
TranscriptomicsTranscriptomic effects of caspase cleavage at TFIIB residue D207 during apoptosis and KSHV infection [TFIIB(D207A)]
Cellular stressors often cause widespread repression of RNA polymerase II (RNAP II) activity, which is thought to facilitate a focused transcriptional output towards stress resolution. In many cases, however, the underlying regulatory mechanisms remain unknown. Here, we demonstrate that stress-induc...
ORGANISM(S): Homo sapiens 
2026-02-01 | GSE250393 | GEO
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