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TranscriptomicsTGF-b signaling and response
This work evaluates new and specific therapeutic targets and molecular diagnostic markers connected to the TGF-b response system in chronic fibrotic diseases.
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-579 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b
TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the indu...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-19601 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs regulated by TGF-b in human CD8+ T cells (small RNA-seq)
The goal of the current study was to identify miRNAs regulated by TGF-b in human CD8+ T cells and analyze the function of these miRNAs in shaping the immunomodulatory effect of TGF-b in these cells. We identified the miR-23a cluster to be upregulated and found that this cluster could target key mole...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-46322 | biostudies-arrayexpress
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
GenomicsMyeloid TGF-b signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis
Myeloid TGF-b signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis
PRJNA1142583 | ENA
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
GenomicsHuman intraepithelial mast cell differentiation and effector function are directed by TGF-b signaling
Human intraepithelial mast cell differentiation and effector function are directed by TGF-b signaling
PRJNA1171463 | ENA
TranscriptomicsTranscriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis via TGF-b-TAK1-depdendent Mechanism
Transforming growth factor-b (TGF-b) regulates various aspects of vascular development, yet the signaling mechanisms of TGF-b in the control of angiogenesis remain poorly characterized. Here we show that homeodomain interacting protein kinases, HIPK1 and HIPK2, are transcriptional corepressors that ...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-39253 | biostudies-arrayexpress
ProteomicsAldehydes alter TGF-b signaling and induce obesity and cancer
Obesity and fatty liver diseases—metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)—affect over one-third of the global population and are exacerbated in individuals with reduced functional aldehyde dehydrogenase 2 (ALDH2), ob...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055145 | Pride
Sptbn1 aldehydes 4-hydroxynonenal 
GenomicsProtein Tyrosine Phosphatase Non-receptor 3 Acts as a Tumor Suppressor and Boosts TGF-b Signaling Independent of its Phosphatase Activity
Protein Tyrosine Phosphatase Non-receptor 3 Acts as a Tumor Suppressor and Boosts TGF-b Signaling Independent of its Phosphatase Activity
PRJNA525769 | ENA
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