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TranscriptomicsRegulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans
BACKGROUND: When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. : We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFbeta mutant...
ORGANISM(S): Caenorhabditis elegans 
2006-02-02 | E-GEOD-4164 | biostudies-arrayexpress
TranscriptomicsTGFbeta signalling in fibroblasts.
Murine embryonic fibroblasts, wild type or Alk5 knock outs, stimulated and unstimulated with TGFbeta.
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1742 | biostudies-arrayexpress
ProteomicsUnderstanding the role of TGFbeta signaling on aortic aneurysm and rupture using Marfan syndrome mouse models
Although abnormal TGFbeta signaling is observed in several heritable forms of thoracic aortic aneurysms and dissections including Marfan syndrome, the precise role of TGFbeta signaling in aortic disease progression is still disputed. Using a mouse genetic approach and quantitative isobaric labeling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD036222 | Pride
Mouse models Marfan syndrome Psr-ohsu Tgfbeta signaling Fibrillin Quantitative proteomics Aortic aneurysm and dissection Tandem mass tags 
TranscriptomicsExpression data from TGFbeta-treated control or aPKC silenced A549 cells
Aberrant TGFbeta signalling is a hallmark of epithelial derived tumours. Signalling patterns can depend on the membrane trafficking and internalization of the TGFbeta receptors. Protein kinase C (PKC), particularly the atypical PKC isoforms, alter the trafficking of TGFbeta receptors and can alter T...
ORGANISM(S): Homo sapiens 
2011-01-29 | E-GEOD-26241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans wild type L2 or L3 larvae (non-dauer) vs TGFbeta mutants at similar developmental stages undergoing dauer formation
BACKGROUND: When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. RESULTS: We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFbeta...
ORGANISM(S): Caenorhabditis elegans 
2006-01-06 | E-SMDB-3596 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human epithelial cell lines treated with TGFbeta
TGFbeta responses of various epithelial cells. No raw data has been provided for this experiment.
ORGANISM(S): Homo sapiens 
2008-10-01 | E-TABM-420 | biostudies-arrayexpress
UnknownCritical regulation of TGFbeta signaling by Hsp90.
Not available
S-EPMC2453700 | biostudies-literature
TranscriptomicsRNAi profiling by array of of Smad2 and Smad3 in mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition
Effects of Smad3 and Smad2 knock-down on TGFbeta-induced epithelial-to-mesenchymal transition (EMT) in mouse mammary epithelial (Nme) cells
ORGANISM(S): Mus musculus 
2009-04-01 | E-MEXP-1342 | biostudies-arrayexpress
UnknownPPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.
Not available
S-EPMC6309366 | biostudies-literature
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Agilent]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36554 | biostudies-arrayexpress
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