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ProteomicsProteomic Profiling of Concurrently Isolated Primary Microvascular Endothelial Cells, Pericytes, and Smooth Muscle Cells from Adult Mouse Heart (ALK1571, PSR-OHSU)
The microcirculation serves crucial functions in adult heart that are distinct from those carried out by epicardial vessels. Microvessels are also governed by unique regulatory mechanisms, impairment of which leads to microvessel-specific pathology. While great progress has been made in understandin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD026673 | Pride
Primary culture Vascular smooth muscle cells Mouse heart Pericytes Psr-ohsu Endothelial cells Tmt labeling Microvascular Quantitative proteomics 
ProteomicsPlatelet proteome dynamics in hibernating 13-lined ground squirrels
Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor and must suppress hemostasis to avoid stasis blood clotting. In addition, cold storage of most mammalian platelets induces cold storage lesions, resulting in rapid clearance following transfusion. 13-lined ground...
ORGANISM(S): Ictidomys tridecemlineatus arenicola 
2021-12-08 | PXD026903 | Pride
Platelets Platelet cold storage Psr-ohsu Platelet transfusion Hibernation Torpor Tmt labeling Quantitative proteomics 
ProteomicsProfiling proteome changes during polyamine depletion within the Leishmania donovani polyamine pathway gene deletion mutants, del-odc (ornithine decarboxylase) and del-spdsyn (spermidine synthase)
Polyamines are aliphatic polycations that have emerged as important determinants of cell growth and viability in rapidly proliferating cells, including in the pathogenic protozoan parasite Leishmania donovani. In L. donovani, the polyamine spermidine is synthesized by the successive conversion of or...
ORGANISM(S): Leishmania donovani BPK282A1 
2022-08-29 | PXD036349 | Pride
Psr-ohsu Leishmania Starvation Ornithine decarboxylase Stress-response Spermidine synthase Quantitative proteomics Polyamine Tandem mass tags 
ProteomicsCompositional analysis of extracellular aggregates in the eyes of patients with exfoliation syndrome and exfoliation glaucoma.
Exfoliation syndrome (XFS) is a condition characterized by the production of insoluble fibrillar aggregates (exfoliation material; XFM) in the eye and elsewhere. Many patients with XFS progress to exfoliation glaucoma (XFG), a significant cause of global blindness. We used quantitative mass spectrom...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026764 | Pride
Human Exfoliation syndrome Shotgun proteomics Psr-ohsu Lens capsule Aqueous humor Tmt labeling Quantitative proteomics Exfoliation glaucoma 
ProteomicsUnderstanding the role of TGFbeta signaling on aortic aneurysm and rupture using Marfan syndrome mouse models
Although abnormal TGFbeta signaling is observed in several heritable forms of thoracic aortic aneurysms and dissections including Marfan syndrome, the precise role of TGFbeta signaling in aortic disease progression is still disputed. Using a mouse genetic approach and quantitative isobaric labeling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD036222 | Pride
Mouse models Marfan syndrome Psr-ohsu Tgfbeta signaling Fibrillin Quantitative proteomics Aortic aneurysm and dissection Tandem mass tags 
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