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ProteomicsSILAC-Based Quantification of TGFBR2-Dependent Protein Expression in Extracellular Vesicles of Microsatellite Unstable Colorectal Cancers
Microsatellite unstable (MSI) colorectal cancers (CRCs) are characterized by Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) deficiency. TGFBR2-deficient CRCs present altered target gene and protein expression. Such cellular alterations modulate the content of CRC-derived extracellular vesi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD013980 | Pride
Proteomics Extracellular vesicles Silac Microsatellite instability Colorectal cancer 
ProteomicsTGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopit...
ORGANISM(S): Homo sapiens (Human) 
2017-04-07 | PXD005620 | Pride
Dna mismatch repair deficiency Lc-msms Transforming growth factor beta receptor type 2 Colorectal cancer Microsatellite instability Exosomes Proteomics 
TranscriptomicsHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression Gene expression of the following mouse livers were characterized A. WT (n=3). B. Pten-/- (n...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-66717 | biostudies-arrayexpress
TranscriptomicsRNA-Seq data from human GBM stem-like cells expressing transgenice TGFBR2
The goal of this experiment was to determine genes regulated by TGFBR2 in glioma stem-like cell. GBM1A (1A) and GBM1B (1B) were transduced with lentivirus to generate stable transgenic lines expressing TGFBR2 (1A-R2 and 1B-R2). Briefly, HEK293FT were co-transfected with second-generation lentiviral ...
ORGANISM(S): Homo sapiens 
2025-04-02 | E-MTAB-14965 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Tgfbr2 mutant mouse models of cleft palate
The overall goal of this project is to investigate the role of TGF-beta signaling in palate development in order to discover candidate therapeutics for preventing and treating congenital birth defects. Here, we conducted gene expression profiling of embryonic palatal tissue from wild type mice as we...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-22989 | biostudies-arrayexpress
GenomicsExpression profiling of microglia lacking Tgfbr2
Expression profiling of microglia lacking Tgfbr2
PRJNA514041 | ENA
GenomicsTranscriptional profiling of endothelial cells lacking Tgfbr2
Transcriptional profiling of endothelial cells lacking Tgfbr2
PRJNA610654 | ENA
ProteomicsTgfbr2 in dental pulp cells guides neurite outgrowth in developing teeth
Transforming growth factor (TGF) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the DP. This process is tightly linked with dentin f...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD031046 | Pride
Dental pulp Neurotrophins Neurite outgrowth Tgfbeta signaling Trigeminal Tooth development Sensory innervation Semaphorins Tgfbeta 
GenomicsmRNA-seq of Tgfbr2 KO CD8 T cells (d30)
mRNA-seq of Tgfbr2 KO CD8 T cells (d30)
PRJNA861296 | ENA
GenomicsMicroglial gene expression after conditional deletion of Tgfbr2 in vivo
Microglial gene expression after conditional deletion of Tgfbr2 in vivo
PRJNA475957 | ENA
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