Sort   by:  
 Page size 
TranscriptomicsTH-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been lim...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-42548 | biostudies-arrayexpress
TranscriptomicsTH-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been lim...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-42254 | biostudies-arrayexpress
ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - Th-MycN tumour proteomics
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conducted pathway-level ana...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-30 | PXD063661 | Pride
Nmt inhibitor Th-mycn Nmt N-myristoylation 
TranscriptomicsGene expression profiling of MYCN-driven neuroblastoma tumor development in the TH-MYCN mouse model.
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system progenitor cells. MYCN and ALK are driver oncogenes both of which are specifically expressed during early neurogenesis. This is in line with the assumption that neuroblastoma arises through disruption of normal deve...
ORGANISM(S): Mus musculus 
2016-02-28 | E-MTAB-3247 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of neuroblastoma Th-MYCN mouse model, samples sensitive to chemotherapy, and those with chemotherapy resistance
Some neuroblastoma patients relapse after chemotherapy. Here, a Th-MYCNCPM32 mouse model usually have spontaneously tumours which are sensitive to chemotherapy. By treating mice with consecutive cycles of sublethal cyclophosphamide (CPM) using a personal dose escalation protocol (PDE), resistant tum...
ORGANISM(S): Mus musculus 
2018-09-30 | E-MTAB-5858 | biostudies-arrayexpress
TranscriptomicsStudy of gene expression changes in TH-MYCN murine neuroblastomas in response to 24hr of panobinostat treatment
Neuroblastoma is the most common extra-cranial malignancy in childhood and accounts for approximately 15% of childhood cancer deaths. Amplification of N-Myc in neuroblastoma is associated with aggressive disease and predicts for poor prognosis. Novel therapeutic approaches are therefore essential to...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69869 | biostudies-arrayexpress
TranscriptomicsMYCN-transformed neuroblasts from TH-MYCN mice are selectively isolated and maintained as spheres in vitro
It has been already reported that there are undifferentiated/proliferating neuroblasts in the postnatal sympathetic ganglia in TH-MYCN mice. We established suitable spheroid culture condition that selectively isolates undifferentiated neuroblasts from superior mesenteric ganligon (SMG) of TH-MYCN mi...
ORGANISM(S): Mus musculus 
2017-04-01 | GSE87782 | GEO
GenomicsArray comparative genomic hybridization of spheres derived from TH-MYCN (hemizygote) mice [Agilent-027441]
It has been already reported that there are undifferentiated/proliferating neuroblasts in the postnatal sympathetic ganglia in TH-MYCN mice, a neuroblastoma model. We established suitable spheroid culture condition that selectively isolates undifferentiated neuroblasts from superior mesenteric ganli...
ORGANISM(S): Mus musculus 
2017-04-01 | GSE89740 | GEO
GenomicsRNA-seq of TH-MYCN driven neuroblastoma mice +/- ALK F1178S mutation and +/- ALKAL2 overexpression
RNA-seq of TH-MYCN driven neuroblastoma mice +/- ALK F1178S mutation and +/- ALKAL2 overexpression
PRJEB40634 | ENA
TranscriptomicsExpression data from neuroblastoma of TH-MYCN/KI RetM919T mice
The RET gene has been identified previously as a target of activated ALK at the mRNA level in both human neuroblastoma cell lines and primary tumors as well as in murine tumors driven by mutated Alk and MYCN. Moreover, it has been shown that tumor growth of murine TH-MYCN/KI Alkmut tumors was impair...
ORGANISM(S): Mus musculus 
2017-09-15 | GSE72678 | GEO
Sort   by:  
 Page size