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UnknownMTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.
Not available
S-EPMC9397639 | biostudies-literature
UnknownTH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.
Not available
S-EPMC7063190 | biostudies-literature
UnknownOverexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer.
Not available
S-EPMC9775511 | biostudies-literature
ProteomicsMass spectrometry analysis of MTH1 inhibitor TH1579 in keratinocytes
MutT Homolog 1 (MTH1) prevents the incorporation of oxidized nucleotide triphosphates into genomic DNA as an antioxidant defense mechanism. The induced expression of MTH1 in psoriatic skin highlights the altered redox regulation and supports the idea of targeted intervention. Thus, MTH1 inhibition c...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD061700 | Pride
Keratinocytes Th1579 Psoriasis Mass spectrometry Mth1i 
ProteomicsCETSA proteomics to investigate drug binding in BJ Ras Sv40 cells treated with MTH1 inhibitors.
Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidative nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cance...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004541 | Pride
Proteomics Lc-ms Bj ras sv40 cells Cetsa Human 
UnknownAdaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion.
Not available
S-EPMC8616547 | biostudies-literature
UnknownMTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Not available
S-EPMC8738733 | biostudies-literature
UnknownPharmacological inhibition of MutT homolog 1 (MTH1) in allergic airway inflammation as a novel treatment strategy.
Not available
S-EPMC11909806 | biostudies-literature
UnknownKaronudib has potent anti-tumor effects in preclinical models of B-cell lymphoma.
Not available
S-EPMC7973795 | biostudies-literature
TranscriptomicsPreclinical efficacy of the MTH1 inhibitor karonudib in B-cell lymphoma
Although chemo-immunotherapy has greatly improved survival of B-cell lymphoma patients, treatment resistant and refractory disease represent a major challenge that call for development of new treatment options. Karonudib (TH1579) is a new drug developed to inhibit MTH1, an enzyme which prevents oxid...
ORGANISM(S): Homo sapiens 
2018-12-07 | GSE123449 | GEO
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