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TranscriptomicsThalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Purpose: Because dexamethasone remains a key component of myeloma therapy, we wished to examine the correlation of baseline and relapse expression levels of the glucocorticoid receptor gene NR3C1 with other clinical features. Experimental Design: We investigated the clinical impact of gene express...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-38627 | biostudies-arrayexpress
TranscriptomicsFetal malformations and early embryonic gene expression response in Cynomolgus monkeys maternally exposed to thalidomide
EXPERIMENT: The animal experiments were performed at Shin Nippon Biomedical Laboratories (SNBL), Ltd. (Kagoshima, Japan) in compliance with the Guideline for Animal Experimentation (1987), and in accordance with the Law Concerning the Protection and Control of Animals (1973) and the Standards Relati...
ORGANISM(S): Macaca fascicularis 
2010-06-20 | E-GEOD-15542 | biostudies-arrayexpress
UnknownPeripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy.
Not available
S-EPMC4839770 | biostudies-literature
ProteomicsThalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome, part 1
Frequently used to treat morning sickness, the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment, however, the molecular basis underlying the pleiotropic biolog...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD010416 | Pride
Crl4 Thalidomide Ubiquitin Imids Cullin 
ProteomicsThalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome, part 2
Frequently used to treat morning sickness, the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment, however, the molecular basis underlying the pleiotropic biolog...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD010417 | Pride
Crl4 Thalidomide Ubiquitin Imids Cullin 
ProteomicsThalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome, part 3
Frequently used to treat morning sickness, the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment, however, the molecular basis underlying the pleiotropic biolog...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD010418 | Pride
Crl4 Thalidomide Ubiquitin Imids Cullin 
ProteomicsThalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome, part 6
Frequently used to treat morning sickness, the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment, however, the molecular basis underlying the pleiotropic biolog...
ORGANISM(S): Homo sapiens (Human) 
2018-08-10 | PXD010428 | Pride
Crl4 Thalidomide Ubiquitin Imids Cullin 
ProteomicsThalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome, part 5
Frequently used to treat morning sickness, the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment, however, the molecular basis underlying the pleiotropic biolog...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD010420 | Pride
Crl4 Thalidomide Ubiquitin Imids Cullin 
TranscriptomicsIdentification of thalidomide modulation related genes in mesenchymal stem cells
Comparison of gene expression data from thalidomide modulated- and unmodulated-MSCs from patients with idiopathic thrombocytopenic purpura (ITP). This experiment consists of 3 arrays.
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-44948 | biostudies-arrayexpress
TranscriptomicsInhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo
The cell differentiation potential of 13-cis retinoic acid (RA) has not succeeded in the clinical treatment of glioblastoma (GBM) so far. However, RA may also induce the expression of disistance genes such as HOXB7 which can be suppressed by Thalidomide (THAL). Therefore, we tested if combined treat...
ORGANISM(S): Homo sapiens 
2015-07-23 | E-GEOD-71224 | biostudies-arrayexpress
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