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TranscriptomicsGene expression profiles of Themis-deficient thymocytes
Determine the biochemical cause of impaired development of Themis-deficient thymocytes. We isolated three thymocyte populations (three populations: CD4+CD8+CD5loCD69lo, CD4+CD8+CD5+CD69+, and CD4+CD8-CD24hiH2Klo) from Themis-deficient and WT mice. 8 or 9 individual biological replicates were analyze...
ORGANISM(S): Mus musculus 
2009-09-14 | E-GEOD-15246 | biostudies-arrayexpress
ProteomicsA Themis:SHP complex promotes T cell survival
THEMIS is critical for conventional T cell development but its precise molecular function remains elusive. Here we show that THEMIS constitutively associates with the phosphatases SHP-1 and SHP-2. This complex requires the adapter GRB2, which bridges SHP to Themis in a Tyr-phosphorylation-independen...
ORGANISM(S): Homo sapiens (Human) 
2015-01-07 | PXD001410 | Pride
Themis Tcr Negative feedback Apoptosis Shp1 
ProteomicsTHEMIS is a novel substrate and allosteric activator of SHP1, playing dual roles during T cell development
By combining strategies of substrate trapping for PTPs and pupylation-based interaction tagging (PUP-IT) for protein-protein interaction, we develop a systematic proximity labeling methodology PEPSI in identifying novel substrate for PTPs. We apply this approach to SHP1 and surprisingly, identified ...
ORGANISM(S): Homo Sapiens 
2023-08-31 | PXD028689 |
GenomicsCRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
CRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
PRJNA1430406 | ENA
TranscriptomicsGene expression profiles of Themis-deficient thymocytes
Determine the biochemical cause of impaired development of Themis-deficient thymocytes.
ORGANISM(S): Mus musculus 
2009-09-14 | GSE15246 | GEO
UnknownA THEMIS:SHP1 complex promotes T-cell survival.
Not available
S-EPMC4339124 | biostudies-literature
UnknownThemis-associated phosphatase activity controls signaling in T cell development.
Not available
S-EPMC6275480 | biostudies-literature
GenomicsBulk RNA-seq profiling of mouse livers with Themis ablation under MASH diet feeding condition
Bulk RNA-seq profiling of mouse livers with Themis ablation under MASH diet feeding condition
PRJNA1279123 | ENA
OtherCRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
THEMIS is an essential T-cell receptor signal modulator critical for T-cell development and peripheral homeostasis; however, the machinery governing its protein stability remains elusive. Utilizing unbiased CRISPR/Cas9 screening integrated with affinity purification-mass spectrometry, we identify UB...
ORGANISM(S): Homo sapiens 
2026-04-30 | GSE322555 | GEO
UnknownDifferential function of Themis CABIT domains during T cell development.
Not available
S-EPMC3931654 | biostudies-literature
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