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ProteomicsIn situ analysis of osmolyte mechanisms of proteome thermal stabilisation
Organisms across all kingdoms of life use small organic molecules called osmolytes to adapt to diverse environmental conditions and preserve viability. Osmolytes are thought to thermally stabilise proteins based on in vitro studies of a few purified proteins. The molecular mechanisms of osmolytes re...
ORGANISM(S): Escherichia coli 
2024-08-09 | PXD036186 | Pride
Osmolyte mechanisms Structural proteomics Stress adaptation Thermal stabilisation Aggregation 
ProteomicsA Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
Benchmarking different LFQ-DIA approaches with traditional TMT-DDA for thermal proteome profiling.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040173 | Pride
Hybrid library Target deconvolution Data-dependent acquisition (dda) Tandem mass tag (tmt) Thermal proteome profiling (tpp) Acute myeloid leukaemia (aml) Spectral library Data-independent acquisition (dia) 
UnknownThermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives.
Not available
S-EPMC9561273 | biostudies-literature
ProteomicsThermal proteome profiling of MMV897615
The target deconvolution of MMV897615 was evaluated using thermal proteome profiling (TPP), a chemical proteomics approach based on the stabilisation of protein targets upon ligand binding. In these TPP experiments we used a whole-cell strategy, exposing cells rather than lysates to the drug
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2023-03-09 | PXD034937 | Pride
Acyl-coa synthetases Drug target Thermal proteome profiling Plasmodium falciparum 
UnknownThermal stabilisation of cocoa fruit pulp - Effects on sensory properties, colour and microbiological stability.
Not available
S-EPMC10382628 | biostudies-literature
ProteomicsIntact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum
Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-17 | PXD059612 | JPOST Repository
UnknownCharacterisation and Stabilisation Mechanisms of Azelaic Acid Nanosuspensions: Insights from a Dual Stabiliser System.
Not available
S-EPMC12030390 | biostudies-literature
UnknownSynergistic effects of bacterial consortium and thermal energy on treatment of sewage by waste stabilisation pond.
Not available
S-EPMC10470288 | biostudies-literature
UnknownOptimal Time Period to Achieve Temperature Stabilisation After Total Contact Cast (TCC) Removal for Assessing Dermal Temperatures in Active Charcot Neuro-Osteoarthropathy.
Not available
S-EPMC12461229 | biostudies-literature
UnknownThermal resilience of ensilicated lysozyme <i>via</i> calorimetric and <i>in vivo</i> analysis.
Not available
S-EPMC9056174 | biostudies-literature
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