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ProteomicsProximity biotinylation and LC-MSMS identification of the molecular microenvironment of coronavirus replication complexes
To investigate virus-host interactions at the site of coronavirus replication, we developed a biotin-based proximity labelling approach by engineering a promiscuous biotin ligase, BirA-R118G, within the coronavirus replication and transcription complex (RTC). BirA-R118G was fused to non-structural p...
ORGANISM(S): Murine hepatitis virus strain A59 Mus musculus (Mouse) 
2019-01-16 | PXD009975 | Pride
L929 mouse fibroblast Lc-msms Viral replication complex Bira-r118g Mouse hepatitis virus Bioid 
TranscriptomicsComprehensive array CGH of normal karyotype Myelodysplastic syndrome reveals hidden recurrent and individual genomic copy number aberrations with prognostic relevance
About 40% of patients with myelodysplastic syndromes (MDS) present with a normal karyotype and they are facing different courses of disease. To advance the biological understanding and find molecular prognostic markers we performed a high resolution oligonucleotide array study of 107 MDS patients (F...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-24602 | biostudies-arrayexpress
ProteomicsProximity labeling and LC-MS/MS based identification of the stress granule microenvironment induced by different viruses
To dissect and compare the protein composition of stress granules formed during infections with two different RNA viruses as well as oxidative stress, we developed a recombinant mouse fibroblast cell line stably expressing a fusion protein of the stress granule marker G3BP1 with APEX2 and GFP. When ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-07 | PXD077432 | Pride
Proximity labeling Mouse hepatitis virus Semliki forest virus Stress granules 
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