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ProteomicsAspirin Acetylates Thioredoxin Reductase 1 (isoform 4)
Thioredoxin Reductase 1 (isoform 4) was incubated with aspirin for 1 hour at 37 C followed by SDS PAGE. Samples were picked from SDS PAGE gel, digested with trypsin, and sent for LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027882 | Pride
Thioredoxin reductase Acetylation Aspirin 
TranscriptomicsRole of thioredoxin reductase in the Yap1p-dependent response to oxidative stress
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-07-22 | E-GEOD-2977 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mutations in the yeast TRR1 gene encoding thioredoxin reductase
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-30 | E-SMDB-2716 | biostudies-arrayexpress
TranscriptomicsShifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were ...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-37874 | biostudies-arrayexpress
Transcriptomicsntr-Transcriptomic study of a thioredoxin reductase knock-out mutant.
rs04-02_ntr - ntr - Thioredoxins are small redox proteins implicated in crucial pathways of cell life. They are reduced by a conserved flavoprotein named NADPH-dependent thioredoxin reductase (NTR). In order to give an insight into the functions of the NTR/thioredoxin pathway in Arabidopsis, we have...
ORGANISM(S): Arabidopsis thaliana 
2007-06-19 | E-GEOD-7998 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thioredoxin reductase knock-out mutant
Transcriptomic study of a thioredoxin reductase knock-out mutant.

Biological question :
Thioredoxins are small redox proteins implicated in crucial pathways of cell life. They are reduced by a conserved flavoprotein named NADPH-dependent thioredoxin reductase (NTR). In order to give an ...
ORGANISM(S): Arabidopsis thaliana 
2005-09-15 | E-MEXP-365 | biostudies-arrayexpress
TranscriptomicsEffects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression
The involvement the thioredoxin system in radiation resistance was investigated in human lung cancer cells by a combination of ionizing radiation and specific thioredoxin reductase-inhibition by a phosphine gold compound. Gene expression profiles (Human Gene 1.0 ST) of lung cancer cells subjected to...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-25814 | biostudies-arrayexpress
GenomicsInhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis 1
Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis 1
PRJNA1188133 | ENA
TranscriptomicsTranscription profiling of wild type and ntrc mutant Arabidopsis seedlings and leaves grown under different photoperiods
Arabidopsis thaliana wildtype (Col-0) was compared with the ntrc mutant under different photoperiods (short day: 8h/16h; long day 16h/8h light/dark) and different ages (10d and 28/21d).
ORGANISM(S): Arabidopsis thaliana 
2009-06-02 | E-MEXP-1697 | biostudies-arrayexpress
ProteomicsComprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than Auranofin
Anticancer drugs that target cellular antioxidant systems have recently attracted much attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer agent and targets the cytosolic and mitochondrial forms of the selenoprotein thioredoxin reductase, Txnrd1 and Txnrd2. R...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-15 | PXD028398 | Pride
Inhibition Thioredoxin reductase Cancer Proteomics Mouse 
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