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MetabolomicsA thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice
Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we showed that Serinc2, a BD susceptibility gene encoding a L-serine transporter that regulates membrane lipid synthes...
2026-07-06 | MTBLS14954 | MetaboLights
TranscriptomicsRole of thioredoxin reductase in the Yap1p-dependent response to oxidative stress
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-07-22 | E-GEOD-2977 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mutations in the yeast TRR1 gene encoding thioredoxin reductase
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-30 | E-SMDB-2716 | biostudies-arrayexpress
TranscriptomicsShifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were ...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-37874 | biostudies-arrayexpress
Transcriptomicsntr-Transcriptomic study of a thioredoxin reductase knock-out mutant.
rs04-02_ntr - ntr - Thioredoxins are small redox proteins implicated in crucial pathways of cell life. They are reduced by a conserved flavoprotein named NADPH-dependent thioredoxin reductase (NTR). In order to give an insight into the functions of the NTR/thioredoxin pathway in Arabidopsis, we have...
ORGANISM(S): Arabidopsis thaliana 
2007-06-19 | E-GEOD-7998 | biostudies-arrayexpress
TranscriptomicsEffects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression
The involvement the thioredoxin system in radiation resistance was investigated in human lung cancer cells by a combination of ionizing radiation and specific thioredoxin reductase-inhibition by a phosphine gold compound. Gene expression profiles (Human Gene 1.0 ST) of lung cancer cells subjected to...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-25814 | biostudies-arrayexpress
ProteomicsDiverse Compounds from Pleuromutilin Lead to a Thioredoxin Inhibitor and Inducer of Ferroptosis
The chemical diversification of natural products provides a robust and general method for creation of stereochemically complex and structurally diverse small molecules. The resulting compounds have physicochemical traits different from those in most screening collections, and as such are a rich sour...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012805 | Pride
Ferroptosis Thioredoxin 
TranscriptomicsFunctions and adaptive responses to oxidative stress of the thioredoxin and glutathione pathways in Clostridium acetobutylicum
Oxidative stress is harmful for organism and occurs when the cells exposed to superoxid, hydrogen peroxide and alkylhydroperoxides. In microorganism, the glutathione- and thioredoxin-dependent reduction systems are universal and play an important role in response to defending oxidative stress. The _...
ORGANISM(S): Clostridium acetobutylicum ATCC 824 
2015-04-13 | E-MTAB-2747 | biostudies-arrayexpress
GenomicsThe thioredoxin-1 system is essential for fueling DNA synthesis during T cell metabolic reprogramming and proliferation
The thioredoxin-1 system is essential for fueling DNA synthesis during T cell metabolic reprogramming and proliferation
PRJNA418977 | ENA
ProteomicsHypoxia reveals the new function of Foxn1 in keratinocytes antioxidant defense system
Skin exposed to environmental threats including injuries and oxidative stress developed an efficient but not fully recognized systems of repair and antioxidant protection. In this project we provide evidence that Foxn1 in keratinocytes regulates elements of electron transport chain and participates ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD031125 | Pride
Thioredoxin system Skin Foxn1 Keratinosytes Hypoxia 
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