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ProteomicsHypoxia induces Foxn1 and Mmp-9 expression in keratinocytes: proteomics analysis of mouse keratinocytes transiently activated by Foxn1
Recent studies have shown that transcription factor Foxn1 expressed in keratinocytes is involved in skin wound healing process, yet how Foxn1 functions remains largely unknown. Proteomic analysis using a two-dimensional differential gel electrophoresis (2D-DIGE) technique coupled with MALDI-TOF/TOF ...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-09 | PXD007843 | Pride
Proteomics Skin Wound healing Hypoxia Mmp-9 Foxn1 
TranscriptomicsGene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177)
Comparative gene expression profiling of thymocytes at the DP, CD4 SP and CD8 SP stage derived from FoxN1-Gpr177 mice (FoxN1-Cre mediated deletion of (Exon3 of) Gpr177/Wtls) or C57Bl/6N mice as comparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymoc...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-69766 | biostudies-arrayexpress
ProteomicsHypoxia reveals the new function of Foxn1 in keratinocytes antioxidant defense system
Skin exposed to environmental threats including injuries and oxidative stress developed an efficient but not fully recognized systems of repair and antioxidant protection. In this project we provide evidence that Foxn1 in keratinocytes regulates elements of electron transport chain and participates ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD031125 | Pride
Thioredoxin system Skin Foxn1 Keratinosytes Hypoxia 
GenomicsFoxn1 choreographs both early and late events in thymic lympho-stromal cross-talk
Normal thymic T cell development is enabled by a stromal microenvironment most importantly composed of distinct epithelial cell populations in cortex and medulla. Their differentiation, growth and function require the expression of the transcription factor Foxn1. Direct targets of Foxn1 have, howeve...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-75219 | biostudies-arrayexpress
ProteomicsHypoxia and Foxn1 alter dermal fibroblasts proteomics signature to redirect scar-less to scar-forming skin wound healing in Foxn1-/- mice
Hypoxia is one of the factors that govern reparative vs regenerative skin wound healing. Data-independent acquisition (DIA) experiment was carried out to study the effect of hypoxia and Foxn1 on mice dermal fibroblast proteomics signature and skin wound healing of Foxn1-deficient (Foxn1-/-) mice.
ORGANISM(S): Mus musculus (Mouse) 
2024-06-20 | PXD041939 | Pride
Mus musculus Lc-ms/ms 
ProteomicsA FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
The transcription factor FOXN1 is a master regulator of thymic epithelial cell development and function. Here we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multi-molecular nuclear condensates essential for the factor's transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-29 | PXD025552 | Pride
Forkhead box n1 transcription factor Thymus Immunodeficiency 
TranscriptomicsTranscriptional profile by mRNA microarrays of cervical thymus, thoracic thymus and parathyroid from Foxn1-GFP; Pth-Cre; R26dTomato transgenic mice
Whole mouse genome microarrays from Agilent were used to determine expression profile of whole organ cervical thymus, thoracic thymus and parathyroid from Foxn1-GFP; Pth-Cre; R26dTomato transgenic mice.
ORGANISM(S): Mus musculus 
2015-07-31 | E-MTAB-3751 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human embryonic stem cells
The goal of this study was to document the gene expression profile of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human pluripotent stem cells. Thymic epithelial cells (TECs) play a critical role in T-cell maturation and tolerance induction. The generation of TECs from ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56373 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile by microRNA microarrays of cervical thymus and thoracic thymus from Foxn1- GFP; Pth-Cre;R26dTomato transgenic mice
The microRNA oligo microarrays from Agilent were used to determine the miRNAs expression profile of whole organ cervical and thoracic thymi from Foxn1-GFP; Pth-Cre; R26dTomato transgenic mice.
ORGANISM(S): Mus musculus 
2015-07-31 | E-MTAB-3752 | biostudies-arrayexpress
GenomicsTranscriptional regulation of the thymus master regulator Foxn1 [RNAseq_dev_HFC]
Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_dev_HFC]
PRJNA793580 | ENA
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