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ProteomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation. From exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091157 | MassIVE
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
TranscriptomicsTranscription profiling by array of primary human hepatocytes derived from hepatitis C patients treated with type III interferons (IFNs) for 6 or 24 hours
Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III IFNs in intrinsic antiviral immunity is poorly understood. Here we show that HCV infection of primar...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31193 | biostudies-arrayexpress
TranscriptomicsHBV Infection and DNA Stimulation Induce a Unique Innate Immune Response in Hepatocytes
Background and Aims: Recent identification of intracellular DNA sensing pathways and involvement in numerous diverse disease processes including viral pathogenesis and autoimmunity suggests a role for these processes in liver pathology. The presence of these pathways in the liver and their role in H...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-69590 | biostudies-arrayexpress
UnknownAn international survey of contemporary practices towards fertility assessment and preservation in patients undergoing radical inguinal orchidectomy for testicular cancer.
Not available
S-EPMC11090774 | biostudies-literature
TranscriptomicsRibavirin Treated Huh7.5.1 Cells
The combination of peginterferon and ribavirin is the standard treatment for chronic hepatitis C. Our recent clinical study suggests that ribavirin augments the induction of interferon stimulated genes (ISGs) in patients treated for HCV infection [1]. In order to further characterize the mechanism...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-23031 | biostudies-arrayexpress
UnknownExpansion and somatic hypermutation of B-cell clones in rejected human kidney grafts.
Not available
S-EPMC4188704 | biostudies-literature
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
UnknownTargeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.
Not available
S-EPMC6075827 | biostudies-literature
UnknownAlcohol and tobacco consumption affects bacterial richness in oral cavity mucosa biofilms.
Not available
S-EPMC4186948 | biostudies-literature
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