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ProteomicsTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g. PI3K/AKT/mTOR pathway) drives tumor progression. In this work, the susceptibility of the colon cancer CTC derived cell line, CTC-MCC-41, for AKT and mTOR inhibitors was evalu...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD054001 | Pride
Ctcs  pi3k/akt/mtor pathway  akt isoforms  xenotransplantation model  proteomics  mk2206  rad001  colorectal carcinoma  drug sensitivity assays  dual targeting  personalized medicine  targeted therapy 
ProteomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level - Technical and Biological Validation
Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. To unravel phenotypically relevant MB subtypes, we compiled a harmonized proteome dataset of 167 MBs and integrated findings with DNA methylation and N-glycome data. Six proteome MB sub...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD048767 | Pride
Proteomics Validation Medulloblastoma 
UnknownSystemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases.
Not available
S-EPMC8007827 | biostudies-literature
ProteomicsThe histogenetic origin of malignant cells predicts their cyto-toxicity towards synthetic lethality utilizing the TK.007 system
The efficacy of killing human cancer cells by a modified Herpes-simplex-virus thymidine kinase TK.007/ganciclovir (GCV) system was investigated in malignant cells of different histogenetic origin. The aim was to determine whether different histogenetic origins of cancer cells in them-selves influenc...
ORGANISM(S): Homo sapiens (Human) 
2025-01-17 | PXD052713 | Pride
Chemotherapy  drug resistance  suicide gene transduction  herpes simplex virus thymidine kinase  ganciclovir  functional kinome profiling 
UnknownFeasibility trial of a digital self-management intervention 'My Breathing Matters' to improve asthma-related quality of life for UK primary care patients with asthma.
Not available
S-EPMC6858238 | biostudies-literature
UnknownInteractive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis.
Not available
S-EPMC4876566 | biostudies-literature
ProteomicsRetinoic acid-induced 2 protein contributes to proficient homologous recombination and maintains genomic stability in breast cancer
Genome instability is a fundamental feature and hallmark of cancer associated with aggressiveness, drug resistance and poor prognosis. Here, we provide evidence for an essential function of the Retinoic acid-induced 2 (RAI2) protein as a suppressor of genome instability. Analysis of clinical samples...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD047189 | Pride
Genomic instability Premature mitotic entry Breast cancer Homologous recombination Poly-(adp-ribose) 
TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
UnknownCC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production.
Not available
S-EPMC9386913 | biostudies-literature
UnknownPrognostic stratification of newly diagnosed IDH-mutant gliomas by [18F]fluoroethyltyrosine and [11C]methionine PET: A retrospective, bicentric cohort study.
Not available
S-EPMC12916739 | biostudies-literature
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