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TranscriptomicsTime Course Gene Expression Microarray Analysis of a Mouse B-cell Line (CH12.LX) Activated with Lipopolysaccharide and Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The objective of the study was to characterize gene expression cascade involved in the suppression of B-cell activation and differentiation by 2,3,7,8-tetrachlorodibenzo-p-dixoxin (TCDD). The underlying hypothesis was that multiple nodes in the B-cell differentiation network are directly or indirect...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-21272 | biostudies-arrayexpress
TranscriptomicsChromatin Immunoprecipitation Analysis of Aryl Hydrocarbon Receptor Binding in a Mouse B-cell Line (CH12.LX) Activated with Lipopolysaccharide and Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters differentiation of B cells and suppresses antibody production. The objectives of this study was to use a combination of whole genome, microarray-based chromatin immunoprecipitation (ChIP-on-chip) and time ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23708 | biostudies-arrayexpress
TranscriptomicsTranscriptional Biomarkers to Predict Female Mouse Liver Tumors in Rodent Cancer Bioassays - A 26 Chemical Set
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2010-03-08 | E-GEOD-18858 | biostudies-arrayexpress
GenomicsHes6 drives a critical AR transcriptional program to induce castration resistant prostate cancer through activation of an E2F1-mediated cell cycle network
Castrate-resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c-Myc and the E2F family also play a role in later stage disease. Here we show that Hes6 is up-regulated in aggressive human prost...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-49832 | biostudies-arrayexpress
UnknownEffect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.
Not available
S-EPMC8787685 | biostudies-literature
TranscriptomicsGene expression microarray analysis of rat nasal tissue with time and dose following formaldehyde inhalation
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration- and exposure-duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (FAcetal) and glutathione (GSH) and with histopath...
ORGANISM(S): Rattus norvegicus 
2010-07-28 | E-GEOD-23179 | biostudies-arrayexpress
UnknownFractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial.
Not available
S-EPMC10667325 | biostudies-literature
UnknownAPOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.
Not available
S-EPMC4597099 | biostudies-literature
UnknownCXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial.
Not available
S-EPMC7291447 | biostudies-literature
UnknownImproving Conversations about Parkinson's Dementia.
Not available
S-EPMC11233842 | biostudies-literature
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