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TranscriptomicsStudies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Using genetic engineering tools available for the model organism Aspergillus nidulans, we constructed two recombinant strains; one expressing the model polyketide Penicillium griseofulvum 6-methylsalicylic acid (6-MSA) polyketide synthase gene, and one expressing the 6-MSA gene and overexpressing th...
ORGANISM(S): Emericella nidulans 
2009-02-27 | E-GEOD-12859 | biostudies-arrayexpress
ModelsPassos2010_DNAdamage_CellularSenescence
This is the model described in: Feedback between p21 and reactive oxygen production is necessary for cell senescence. Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. ;M...
2024-09-02 | BIOMD0000000287 | BioModels
TranscriptomicsCharacterization of the inflammatory phenotype of Mycobacterium avium subspecies paratuberculosis
Understanding the pathogenic mechanisms and host responses to Johne's disease, caused by Mycboacterium avium subspecies paratuberculosis (MAP), is complicated by a number of challenges of the disease progression and lack of ex vivo models to study the disease. We describe novel cell culture passage...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2014-11-01 | E-GEOD-62566 | biostudies-arrayexpress
UnknownProfiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.
Not available
S-EPMC7409555 | biostudies-literature
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsGenotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear genome, and anterograde signalling to mitochondria. All these interactions have the potential to influence the freque...
2018-11-07 | MTBLS724 | MetaboLights
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
GenomicsPCGP MB WGS Full - samples
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
EGAD00001001864 | EGA
GenomicsPCGP MB - samples
OLD DATA FILES FOR SJMB - Superseded by EGAD00001001864
EGAD00001000269 | EGA
GenomicsGenetic landscape of pediatric Medulloblastoma
Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whole g...
EGAS00001000347 | EGA
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