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TranscriptomicsAberrant DNA methylation reprogramming during iPS cell generation is dependent on the choice of reprogramming factors
we generate iPSCs from a common fibroblast cell source using either the Yamanaka factors (OCT4, SOX2, KLF4 and MYC) or the Thomson factors (OCT4, SOX2, NANOG and LIN28) and determined their genome-wide DNA methylation profiles. In addition to shared DNA methylation aberrations present in all our iPS...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-54115 | biostudies-arrayexpress
UnknownThree-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial.
Not available
S-EPMC6286164 | biostudies-literature
UnknownCD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.
Not available
S-EPMC2883609 | biostudies-literature
GenomicsGenome-wide demethylation of Arabidopsis endosperm
Parent-of-origin-specific (imprinted) gene expression is regulated in Arabidopsis thaliana endosperm by cytosine demethylation of the maternal genome mediated by the DNA glycosylase DEMETER, but the extent of the methylation changes is not known.  Here we show that virtually the entire endosperm gen...
ORGANISM(S): Arabidopsis thaliana 
2009-06-16 | E-GEOD-15922 | biostudies-arrayexpress
ProteomicsOccupationally Relevant Vibrations and the Brain: Frequency-Dependent Proteomics Signatures in a Rat Model
Occupational exposure to whole-body vibration (WBV), particularly in agricultural settings, has been linked to adverse cognitive and physiological outcomes. This study investigates the neurophysiological effects of WBV using a rat model exposed to sinusoidal vibrations at 4 Hz and 30 Hz, frequencies...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-27 | PXD069749 | Pride
Rat Brain Lc-ms/ms 
UnknownER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity-influenced enhancer.
Not available
S-EPMC12646672 | biostudies-literature
UnknownIntraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.
Not available
S-EPMC7664990 | biostudies-literature
TranscriptomicsGenome-wide transcriptional responses to benzo[a]pyrene and clofibrate in the tunicate Oikopleura dioica
Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics are not known in most invertebrates. Here, using high...
ORGANISM(S): Oikopleura dioica 
2013-02-05 | E-GEOD-33818 | biostudies-arrayexpress
UnknownSenolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions.
Not available
S-EPMC8762039 | biostudies-literature
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
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