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UnknownKL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
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S-EPMC8219708 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embyronic stem cells cultured with PI3-K signalling inhibitor LY294002 to identify PI3K-target genes
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org).The experiment was conducted at the Unyversity of Bath, Bath, UK. Aim of the experiment is the ident...
ORGANISM(S): Mus musculus 
2009-05-07 | E-TABM-673 | biostudies-arrayexpress
TranscriptomicsAn alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme
Most available knowledge on fungal arginine metabolism is derived from studies on Saccharomyces cerevisiae, in which arginine catabolism is initiated by releasing urea via the arginase reaction. Orthologs of the S. cerevisiae genes encoding the first three enzymes in the arginase pathway were cloned...
ORGANISM(S): Kluyveromyces lactis 
2014-07-16 | E-GEOD-56060 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung carcinoma and brain glioblastoma cells were analalyzed, with microarrays run both for control and treatment with dichloroacetate reveals a mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis inhibits cancer growth
The unique metabolic profile of most cancers (aerobic glycolysis) might confer apoptosis-resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential and low expression of the K+ channel Kv1.5, both contributing to apoptosis-r...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6014 | biostudies-arrayexpress
TranscriptomicsVietnam Typhoid Study
Patient Selection: Three hospitals were involved in the study: Dong Thap Provincial and An Giang Provincial hospitals, both located in the Mekong Delta Region of Vietnam where most of the Typhoid patients were admitted, and the Hospital for Tropical Diseases, Ho Chi Minh City, where the malarial pat...
ORGANISM(S): Homo sapiens 
2010-01-03 | E-GEOD-7000 | biostudies-arrayexpress
TranscriptomicsIdentification of copy number alterations associated with the progression of DCIS to Invasive Ductal Carcinoma
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma (IDC). Annotation of the genetic differences between the two lesions may assist in the identification of genes that promote the invasive phenotype. Matched IDC and DCIS showed highly similar copy number profile...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-31892 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embyronic stem cells cultured with PI3-K signalling inhibitor LY294002 for different lengths of time to identify PI3K-target genes
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org).The experiment was conducted at the Unyversity of Bath, Bath, UK. Aim is to identify genes regulated...
ORGANISM(S): Mus musculus 
2009-05-07 | E-TABM-674 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Atlantic salmon infected with salmoin alphavirus
Salmon pancreas disease, caused by salmonid alphavirus (SAV), is an economically important disease affecting farmed Atlantic salmon (Salmo salar L.) in Europe, with outbreaks reported in Scotland, Norway, and Ireland. A microarray-based study was performed to evaluate the host transcriptomic respons...
ORGANISM(S): Salmo salar 
2011-06-01 | E-TABM-1060 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mammary glands from wild type and Akt1 knock out lactating mice at day 9 after parturition
A comparison of gene expression in the mammary gland of lactating mice at day 9 after parturition between Akt -/- and wildtype individuals.
ORGANISM(S): Mus musculus 
2006-12-31 | E-MEXP-891 | biostudies-arrayexpress
Transcriptomicsglobal gene expression profiles in primary human hepatocytes exposed to phytochemicals
Primary human hepatocytes were treated with 2 non-cytotoxic concentrations of sulforaphane (SFN; 10 and 50 uM) phenethyl isothiocyante (PEITC; 10 and 25 uM), 3,3'-diindolylmethane (DIM; 10 and 50 uM), or one concentration of oltipraz (OPZ; 30 uM) for 48 hours. Given the considerable heterogeneity o...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-20479 | biostudies-arrayexpress
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