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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
TranscriptomicsTranscriptomic profiling of Salmonella during lag, exponential and stationary phases of growth
Transcriptional profiles during all phases of growth of Salmonella Typhimurium SL1344 were obtained and used to investigate growth phase-dependent alterations in gene expression. Viable count growth curve analysis of the growth system showed a culture lag time of 2.09 hours, and profiles at 4, 20, 4...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2011-12-13 | E-GEOD-22294 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Arabidopsis Scaffold/Matrix Attachment Regions Reveals Link to Nucleosome-Disfavoring Poly(dA:dT) Tracts
Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of distribution and genomic context of S/MARs is thought to be important for processes such as chromatin organization and modulation of gene expression. Despite the importance of such processes, much is unknown a...
ORGANISM(S): Arabidopsis thaliana 
2014-02-03 | E-GEOD-45549 | biostudies-arrayexpress
UnknownAssessing The Capacity Of Local Social Services Agencies To Respond To Referrals From Health Care Providers.
Not available
S-EPMC8336061 | biostudies-literature
TranscriptomicsCoordinated posttranscriptional mRNA population dynamics during T-cell activation
Although RNA-binding proteins (RBPs) coordinate many key decisions during cell growth and differentiation, the dynamics of RNA–RBP interactions have not been extensively studied on a global basis. We immunoprecipitated endogenous ribonucleoprotein complexes containing HuR and PABP throughout a T-cel...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-11989 | biostudies-arrayexpress
TranscriptomicsEffect of ppGpp on Salmonella Typhimurium gene expression
The expression profile of an S. Typhimurium mutant strain unable to synthesise ppGpp (relAspoT deletions) was compared to the wild-type strain. The effect of ppGpp on virulence gene expression was studied under 4 different growth conditions that induce virulence gene expression. Keywords: genetic mo...
ORGANISM(S): Salmonella typhimurium 
2010-06-11 | E-GEOD-4631 | biostudies-arrayexpress
ProteomicsSod1 Integrates Oxygen Availability to Redox Regulate NADPH Production and the Thiol Redoxome
Redox proteomics identifies additional putative targets of Sod1 redox regulation. The high abundance and broad cellular distribution of Sod1 suggests that it may function as a redox regulator of a broad variety of substrates in addition to GAPDH. To test this, we conducted a high-powered quantitativ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-01-04 | PXD030372 | Pride
Pentose phosphate pathway Superoxide dismutase Oxygen sensing Redox signailng Glycolysis 
TranscriptomicsTemporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R
Precise spatiotemporal control of mRNA translation machinery is essential to proper development of highly complex systems like the neocortex. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a deve...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-50809 | biostudies-arrayexpress
UnknownEvent-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with immunochemotherapy.
Not available
S-EPMC3965261 | biostudies-literature
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
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