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MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
ProteomicsDifferentially expressed proteins wereassociated withtwo color morphs of Asian citrus psyllid, Diaphorina citri
Diaphorina citriis a vector of ‘CandidatusLiberibacter asiaticus,’(CLas), associated with citrus greening or Huanglongbing (HLB) disease in citrus. D. citriexhibits two group three different color morph variants, blueand non-blue (includes gray and yellow). Blue morphs have a greater capacity fo...
ORGANISM(S): Diaphorina citri (Asian citrus psyllid) 
2021-04-26 | PXD017150 | Pride
Color polymorphism Immunity Proteomics survey 
ProteomicsPLRV co-immunoprecipitation from Solanum tuberosum
Phloem localization of plant viruses is advantageous for acquisition by sap-sucking vectors but hampers host-virus protein interaction studies. In this study, Potato leafroll virus (PLRV)-host protein complexes were isolated from systemically infected potato, a natural host of the virus. Comparing t...
ORGANISM(S): Solanum tuberosum (Potato) 
2016-12-14 | PXD004814 | Pride
Host-pathogen interactions Lc-msms Co-immunoprecipitation Luteoviridae Polerovirus Solanum tuberosum Potato leafroll virus Phloem-limited 
ProteomicsBacteria Associated with Russian Wheat Aphid (Diuraphis noxia) Enhance Aphid Virulence to Wheat
Phenotypic responses to biotic stresses are often studied as the interactions between two species; however, in the phytobiome, these responses frequently result from complex interactions involving several organisms. Here, we show that variation in chlorosis caused by Russian wheat aphid (Diuraphis n...
ORGANISM(S): Diuraphis noxia 
2020-11-09 | PXD010663 | Pride
Aphid saliva | proteome | enterobacteriaceae | multitrophic interactions | microbiome | phytobiome 
ProteomicsCovalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C
The discovery of KRAS G12C inactive state inhibitors represents a significant advancement in the field of precision oncology. While inactive state inhibition shows promise in patients, SWII-binding inhibitors targeting both inactive and active states remain an underdeveloped therapeutic modality. H...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD062227 | Pride
MetabolomicsPlasma metabolic profile in COPD patients: effects of exercise and endurance training
The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenerge...
2017-03-10 | MTBLS249 | MetaboLights
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
TranscriptomicsTo identify and study the regulation of cellulosic enzymes in a biomass degrading gut fungal isolate from horse (Piromyces sp. finn)
Here, we develop a systems-level approach leveraging powerful next generation sequencing, proteomics and phenotypic studies to rapidly obtain an integrated view of lignocellulose degradation in the earliest free living fungi RNA-seq of Piromyces grown on Glucose, Cellulose, Cellulobiose, Avicel, Fil...
ORGANISM(S): Piromyces sp. Finn 
2016-02-12 | E-GEOD-64834 | biostudies-arrayexpress
TranscriptomicsHuman thyroid adenomas, carcinomas, and normals
Human samples of various thyroid carcinomas, adenomas, and normals, each from a different patient, had mRNA assays performed using Affymetrix HG_U133A arrays, with 22283 probe-sets. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 onco...
ORGANISM(S): Homo sapiens 
2011-02-09 | E-GEOD-27155 | biostudies-arrayexpress
UnknownEffect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.
Not available
S-EPMC5833549 | biostudies-literature
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