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UnknownThe multi-channel potentiostat: Development and evaluation of a scalable mini-potentiostat array for investigating electrochemical reaction mechanisms.
Not available
S-EPMC8445456 | biostudies-literature
ProteomicsTowards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics
Objective: Head and neck cancer (HNC) accounts for almost 850,000 new cases per year. Radiotherapy (RT) is used to treat the majority of these patients. A common side-effect of RT-treatment is onset of oral mucositis: a painful irritation and swelling in mouth, which decreases the quality of life an...
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD040398 | Pride
Keratinocytes Interferon response Stat phosphorylation Radiotherapy Mass spectrometry-based proteomics Biomarker Mcm complex 
ProteomicsAI-powered Deep Visual Proteomics unmasks critical molecular transitions in pancreatic cancer precursors
Pancreatic ductal adenocarcinoma (PDAC) evolves through precursors, yet the protein programs that govern early progression remain poorly defined. We applied Deep Visual Proteomics - computational pathology, laser microdissection, and mass spectrometry (MS) - to profile normal ducts, acinar-to-ductal...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD072559 | Pride
Deep visual proteomics Laser microdissection Pathology foundation models Mass spectrometry Artificial intelligence Precursor Spatial Tumor Pancreatic ductal adenocarcinoma 
TranscriptomicsSalmonella under environmental stress
The aim of this study is to investigate the transcriptional response of S. Typhimurium to heat, osmotic, oxidative and acid stress under anoxic and oxic conditions and to non-stressed anoxic conditions.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2013-11-11 | E-MTAB-1804 | biostudies-arrayexpress
ProteomicsProteome profiles of primary pancreatic ductal adenocarcinomas undergoing adjuvant chemoradiation link ALDH1A1 to early local recurrence and chemoradiation resistance
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with very frequent post-surgical local recurrence. The combination of adjuvant chemotherapy with radiotherapy is under consideration to achieve a prolonged disease-free survival (DFS). To date, few studies have determined protein profiles ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-11 | PXD009254 | Pride
Maoa Chemoradiation Aldh1a1 
ProteomicsProteomic profiling of TGFBIp-null mouse corneas reveals minor changes in the extracellular matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies
TGFBIp is a constituent of the extracellular matrix in many human tissues including the cornea, where it is one of the most abundant proteins expressed. TGFBIp interacts with type I, II, IV, VI and XII collagens as well as several members of the integrin family, suggesting that it plays an important...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-14 | PXD006494 | Pride
Ecm Tgfbip Cornea Periostin Itraq Lc-ms/ms 
ProteomicsTargeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer
Unfolded protein response (UPR) is a central stress response pathway in normal cells that is hijacked by tumor cells for their survival. However, how activation of UPR in cancer cells shapes the tumor microenvironment (TME) remain largely unexplored. Here, we investigated the role of IRE1α-XBP1s on...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-28 | PXD044287 | Pride
Ire1 prostate cancer tumor microenvironment 
ProteomicsBeta-blocker/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts.
Rationale: The molecular underpinnings of heart failure with reduced ejection fraction (HFrEF) involves a complex remodeling of the contractile, metabolic and electrical functions. Current pharmacotherapy for patients presenting HFrEF includes combination of angiotensin-converting enzyme inhibitors ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD024525 | Pride
Ace inhibitor Hfref Cardiac proteomics ß-ar blocker Phosphoproteomics 
TranscriptomicsCUT&RUN of erythroblasts upon perturbation of gamma-hemoglobin repressors (part II)
Through high throughput compound screening, we've identified compounds that induce the expression of fetal hemoglobin. This study contains CUT&RUN data of a novel target, WIZ.
ORGANISM(S): Homo sapiens 
2024-06-19 | E-MTAB-13890 | biostudies-arrayexpress
UnknownRisk of COVID-19 after natural infection or vaccination.
Not available
S-EPMC10518569 | biostudies-literature
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