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MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
ProteomicsConcomitant deletion of Shp-1 and Shp-2 in T cells fails to improve anticancer responses 
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as programmed cell death protein 1 (PD-1). Blockade of PD-1 signalling leads to T cell reinvigoration and is increasingly applied as an effective anticancer treatment...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD034897 | Pride
Shp-2  shp-1  ptpn11  ptpn6  t cell exhaustion  cancer immunotherapy  inhibitory receptors  pd-1 checkpoint therapy  
ProteomicsExtended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson's disease
Glycosphingolipids (GSLs) are important targets in immune, infectious, lysosomal storage diseases, cancer, and neurodegenerative diseases. Circulatory GSL profiling in clinical samples is restricted by the lack of mid- and high-throughput analytical methods and deep coverage of long-chain sialylated...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-31 | MSV000097015 | MassIVE
OtherTrypanosoma cruzi infection in HeLa cells
Single-probe single cell mass spectrometry (SCMS) analysis contains 3 sets of experiments: 1. SCMS analysis of 4 groups of cells: infected, bystanders, stained and control cells 2. SCMS analysis of 3 groups of cells (2 replicates): infected, correctly classified bystander, misclassified bystander ce...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Trypanosoma Cruzi (ncbitaxon:5693) 
2022-05-20 | MSV000089503 | MassIVE
ProteomicsARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection: SRM_CBFB_CUL2_CUL5_interactors
SRM assays were generated for selected interactors of CUL5, CBFB and ELOB. SRM assay generation was performed using Skyline. For all targeted proteins, proteotypic peptides and optimal transitions for identification and quantification were selected based on the Skyline spectral library generated fro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2020-02-17 | MSV000084965 | MassIVE
ProteomicsARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection: SRM-CUL5
SRM assays were generated for selected interactors of CUL5. SRM assay generation was performed using Skyline. For all targeted proteins, proteotypic peptides and optimal transitions for identification and quantification were selected based on the Skyline spectral library generated from the shotgun M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2020-02-17 | MSV000084963 | MassIVE
ProteomicsARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection: SRM-ELOB
SRM assays were generated for selected interactors of ELOB. SRM assay generation was performed using Skyline. For all targeted proteins, proteotypic peptides and optimal transitions for identification and quantification were selected based on the Skyline spectral library generated from the shotgun M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2020-02-17 | MSV000084962 | MassIVE
ProteomicsARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection: SRM-CBFB
SRM assays were generated for selected interactors of CBFB. SRM assay generation was performed using Skyline. For all targeted proteins, proteotypic peptides and optimal transitions for identification and quantification were selected based on the Skyline spectral library generated from the shotgun M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2020-02-17 | MSV000084964 | MassIVE
UnknownNMDA receptor gene variations as modifiers in Huntington disease: a replication study.
Not available
S-EPMC3186947 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Not available
S-EPMC11320601 | biostudies-literature
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