Thp-1 cell infection

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Unknown (474)
Genomics (97)
Transcriptomics (95)
Proteomics (75)
Metabolomics (3)
Other (2)

Organisms

Homo sapiens (82)
Bombyx mori (66)
Klebsiella pneumoniae (66)
Musca domestica (66)
Schizosaccharomyces pombe (66)
Streptomyces coelicolor A3(2) (66)
Human immunodeficiency virus 1 (66)
Oryza sativa Indica Group (66)
Sinorhizobium meliloti BL225C (66)
Vitis (66)
Mycobacterium tuberculosis (5)
Mycobacterium avium subsp. paratuberculosis (4)
Ehrlichia chaffeensis str. Arkansas (2)
Mycobacterium tuberculosis H37Rv (2)
Mycobacterium avium subsp. paratuberculosis K-10 (2)
Trichophyton rubrum (2)
Mycobacterium tuberculosis variant bovis BCG (1)
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 (1)
Leishmania infantum (1)
Leishmania donovani (1)
Leishmania major (1)
Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 (1)
mixed sample (1)
Streptococcus pneumoniae (1)
Escherichia coli (1)
Ehrlichia chaffeensis (1)
Human immunodeficiency virus (1)
Burkholderia pseudomallei (1)
Human betaherpesvirus 5 (1)
Aspergillus fumigatus (1)

Organisms

Homo sapiens (58)
Ehrlichia chaffeensis str. Arkansas (1)
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 (1)
Enterovirus A71 (1)
Porphyromonas gingivalis (1)
Mycobacterium avium subsp. paratuberculosis (1)
Yersinia pestis (1)
Mycobacterium tuberculosis (1)
Mycobacterium tuberculosis H37Rv (1)
unidentified (1)

Repository

ENA (90)
pride (66)
biostudies-arrayexpress (64)
geo (40)
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PAXDB (1)

Tissue

Cell culture (35)
Macrophage (23)
Monocyte (14)
Blood (6)
Epithelial cell (5)
Mucosal invariant T cell (4)
Primary cell (1)
Permanent cell line cell (1)
Fibroblast (1)
Blood cell (1)
Cell suspension culture (1)
Lung (1)
Keratinocyte (1)
Whole body (1)

Disease

Avian influenza (3)
Influenza (3)
Legionnaires' disease (2)
Tuberculosis (2)
Acute leukemia (2)
Japanese encephalitis (1)
Q fever (1)
Lymphoma (1)
Cystic fibrosis (1)
Glioblastoma (1)

Technology Type

Mass Spectrometry (66)
Shotgun proteomics (32)
Bottom-up proteomics (18)
Affinity purification coupled with mass spectrometry proteomics (9)
Data-dependent acquisition (6)
Data-independent acquisition (4)
DiaPASEF (3)
SWATH MS (3)
Mass spectrometry (2)
Gel-based experiment (2)
SRM/MRM (2)
Mass spectrometry assay (1)
MSE (1)
Mass spectrometry imaging (1)
Immunopeptidomics (1)
Top-down proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Illumina HiSeq 2500 (3)
NextSeq 500 (2)
Orbitrap Fusion (2)
FastPrep-24 5G bead beater, Qubit Fluorometer (1)
12 well TC-treated plate, LETs buffer, dry ice (1)
GenePix Professional 4200A [Axon Instruments] (1)
Ion Torrent Proton (1)
N/A (1)
NextSeq 2000 (1)
Illumina HiSeq 1500 (1)
Illumina NovaSeq 6000 (1)
Illumina HiSeq 2000 (1)
Dionex UltiMate 3000 HPLC (Thermo Scientific instrument model) (1)
EASY-Spray C18 column (1)
LTQ Orbitrap Elite (1)
Orbitrap Exploris 480 (1)
Orbitrap Eclipse (1)
Liquid Chromatography MS - Alternating (LC-MS (Alt)) (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - alternating - hilic (1)

Publication Date

2026 (26)
2023 (19)
2015 (18)
2025 (16)
2010 (15)
2022 (13)
2021 (13)
2012 (8)
2024 (8)
2020 (7)
2016 (6)
2014 (6)
2013 (6)
2017 (5)
2019 (4)
2011 (4)
2008 (3)
2018 (3)
2009 (1)
2006 (1)

UNIPROT ID/AC

Q7VTM5_BORPE (1)
Q7VUH9_BORPE (1)
Q7VUX8_BORPE (1)
Q7VT90_BORPE (1)
Q7VZ34_BORPE (1)
Q7VXP9_BORPE (1)
APAG_BORPE (1)
Q7VUH8_BORPE (1)
Q7VVI7_BORPE (1)
Q7VSL7_BORPE (1)
Q7VSQ5_BORPE (1)
Q7VT25_BORPE (1)
Q7VYL9_BORPE (1)
Q7VZS4_BORPE (1)
Q7VUN3_BORPE (1)
Q7VZ29_BORPE (1)
Q7VYQ9_BORPE (1)
Q7VU40_BORPE (1)
LOLA_BORPE (1)
Q7VWL2_BORPE (1)
Q7VU86_BORPE (1)
Q7VXX1_BORPE (1)
Q7VU33_BORPE (1)
Q7VY16_BORPE (1)
Q7VY32_BORPE (1)
Q7VVJ6_BORPE (1)
Q7VS73_BORPE (1)
Q7VXA4_BORPE (1)
Q7VVI8_BORPE (1)
Q7VRZ4_BORPE (1)

CHEBI ID

CHEBI:16856 (3)
CHEBI:17858 (3)
CHEBI:27997 (2)
CHEBI:46961 (2)
CHEBI:131692 (2)
CHEBI:48430 (2)
CHEBI:17929 (2)
CHEBI:16919 (2)
CHEBI:30769 (2)
CHEBI:16958 (2)
CHEBI:16449 (2)
CHEBI:17368 (2)
CHEBI:83241 (1)
CHEBI:145229 (1)
CHEBI:145862 (1)
CHEBI:88657 (1)
CHEBI:145842 (1)
CHEBI:145843 (1)
CHEBI:29126 (1)
CHEBI:29140 (1)
CHEBI:89689 (1)
CHEBI:145857 (1)
CHEBI:145858 (1)
CHEBI:29866 (1)
CHEBI:145878 (1)
CHEBI:145314 (1)
CHEBI:63410 (1)
CHEBI:145212 (1)
CHEBI:145213 (1)
CHEBI:16382 (1)

Metabolite Name

Glutathione (3)
Elaidic acid (2)
Oxidized glutathione (2)
Creatine (2)
Hypoxanthine (2)
Pantetheine 4-phosphate (1)
PIP2[3',4'](16:0/18:0) (1)
N,N-Diacetylchitobiosyldiphosphodolichol (1)
Guanosine 2,3-cyclic phosphate (1)
UDP-N-Ac-Glucosamine (1)
S-Adenosyl-Methionine (1)
S-Adenosyl-Homocysteine (1)
Ribulose5P (1)
OphthalmicAcid (1)
NMMA (1)
N-Carbamoyl-aspartate (1)
N-Acetylglutamate (1)
HexP (1)
Fructose16bisP (1)
Dihydroxyacetone3P (1)
CYS (1)
B-ALA (1)
AcetylCoA (1)
6P-gluconate (1)
6.0Hexanoyl-L-carnitine (1)
4-Methyl-2-Oxopentanoate (1)
4.0Butyryl-L-carnitine (1)
3.0Propionyl-L-carnitine (1)
2P-glycerate (1)
2.0Acetyl-L-carnitine (1)

First Public Date

2025 (14)
2022 (14)
2014 (12)
2026 (10)
2023 (8)
2021 (7)
2015 (6)
2024 (5)
2017 (5)
2019 (4)
2018 (2)
2016 (2)
2020 (1)

Classification

bacteria (7)
viruses (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (41)
RNA-seq of coding RNA (15)
Unknown experiment type (1)
High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
Comparative genomic hybridization by array (1)
ChIP-seq (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2023 (52)
2022 (50)
2025 (47)
2024 (43)
2015 (42)
2021 (39)
2019 (38)
2016 (35)
2020 (31)
2018 (28)
2017 (27)
2012 (20)
2010 (19)
2014 (14)
2013 (14)
2026 (8)
2011 (8)
2008 (7)
2006 (5)
2009 (3)
2007 (2)
2005 (2)
2003 (2)
2002 (1)
1999 (1)

Lab affiliation

Infection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, VIC 3800, Australia (5)
Cellular Proteomics, Helmholtz Centre for Infection Research, Braunschweig, Germany (4)
VIB-UGent Center for Medical Biotechnology, VIB Ghent, Belgium Department of Biomolecular Medicine, Ghent University, Ghent, Belgium (3)
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia (3)
Technical University of Munich, School of Medicine, Institute of Virology, 81675 Munich, Germany (2)
Department of Microbiology, Immunology and Pathology; Colorado State University, Fort Collins, CO (1)
University Medicine Greifswald, Germany (1)
Medizinisches Proteom-Center Ruhr-Universität Bochum 44801 Bochum Germany (1)
Dept. Cellular Molecular Pharmacology, University of San Francisco (UCSF), USA (1)
Marshall Centre for Infectious Disease Research and Training, School of Biomedical Sciences, The University of Western Australia, Nedlands, Western Australia, 6009, Australia (1)
Team SOAP, CRCI2NA, Nantes University, INSERM, CNRS, Université d'Angers, Nantes, France. Equipe Labellisée Ligue Contre le Cancer, Nantes (1)
Chair of Department of Preventive Veterinary Medicine College of Veterinary Medicine China Agricultural University (CAU) (1)
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China (1)
Interfaculty Institute for Cell Biology Department of Immunology University of Tübingen Auf der Morgenstelle 15 72076 Tübingen Germany (1)
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. (1)
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute Jena, Leibniz-HKI, Adolf-Reichwein-Str. 23, 07745 Jena, Germany (1)
Scientist C & DBT-Ramalingaswami Faculty Fellow Rajiv Gandhi Centre for Biotechnology Campus 2, Aakkulam, Thiruvananthapuram, Kerala, India (1)
Center for neuroscience and cell biology (1)
Department of Biochemistry and Molecular Biology, Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, Oklahoma, USA (1)
Newcastle University Biosciences Institute, UK (1)
1Centre for New Antibacterial Strategies (CANS) & Research Group for Host-Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, UiT- The Arctic University of Norway, 9037 Tromsø (1)
Bioscience Institute,Faculty for Medical Sciences at Newcastle University. Newcastle-Upon-Tyne United Kingdom NE24HH (1)
Deparment of Biochemistry and Molecular Biology, University of British Columbia, Canada (1)
Department of Biochemistry and Molecular Biology, University of British Columbia, Canada (1)
VIB-UGent Center for Medical Biotechnology, VIB, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium. UGent Department of Biomolecular Medicine, Ghent University, Technologiepark-Zwijnaarde, 9052 Ghent, Belgium (1)
University of Manchester, Newcastle University (1)
ICAR-National Bureau of Animal Genetic Resources, Karnal (1)
1DST/NRF Centre of Excellence in Biomedical Tuberculosis research, SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa (1)
DST/NRF Centre of Excellence in Biomedical Tuberculosis research, SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa (1)
Infection and Immunity Program, Monash Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, VIC 3800, Australia (1)

Tags

pathogen (8)
pathogen:bacterium (7)
pathogen:virus (1)

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Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line

Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro THP-1 (ATCC TIB-202) cell line infection, comparing bacteria grown in host medium and intracellular bacteria recovered from infected THP-1 cells. Two-condition experiment, MAP-K vs. intracellular MAP-THP-1. Biolog...

ORGANISM(S): Mycobacterium avium subsp. paratuberculosis

2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress

Dual RNA-seq of M. tuberculosis H37Rv infecting macrophage-like THP-1 cells during 48h

Transcriptional changes during early infection of macrophage-like THP-1 cell line with pathogenic bacterium Mycobacterium tuberculosis. RNAseq samples were taken at 0h (THP-1 cells growing in the RPMI medium), and after 4h, 24h and 48h post infection. Bacterial enrichment was performed to increase t...

ORGANISM(S): Homo sapiens

2017-08-01 | E-MTAB-5287 | biostudies-arrayexpress

Mycobacterium avium subsp. paratuberculosis gene transcription in simulated phagosomal environment and in human macrophage infection

This SuperSeries is composed of the following subset Series: GSE32241: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress GSE32242: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculos...

ORGANISM(S): Mycobacterium avium subsp. paratuberculosis

2012-05-31 | E-GEOD-32243 | biostudies-arrayexpress

Transcriptomics of vitamin D treatment effects in Mycobacterium tuberculosis-infected THP-1 cells

Previous reports have shown low vitamin D serum levels and polymorphisms in the vitamin D receptor (VDR) to be associated with increased risk for TB. Given that 1?,25-dihydroxyvitamin D3 has a role in lipid metabolism control, we tested whether the link between 1?,25-dihydroxyvitamin D3 and tubercul...

ORGANISM(S): Homo sapiens

2014-07-01 | E-GEOD-57028 | biostudies-arrayexpress

Transcription profiling of human cell line THP-1 cells exposed to Daboiatoxin and cytokines involved in melioidosis caused by B. pseudomalli

Gene expression profiles of human cell (THP-1) lines exposed to a novel Daboiatoxin (DbTx) isolated from Daboia russelli russelli, and specific cytokines and inflammatory pathways involved in acute infection caused by Burkholderia pseudomallei. Experiment Overall Design: 1. Group I:- Human monocytic...

ORGANISM(S): Homo sapiens

2009-04-04 | E-GEOD-7577 | biostudies-arrayexpress

LncRNA/mRNA expression profiling for THP-1 macrophages and THP-1 macrophage-derived foam cells

By identifying differentially expressed LncRNAs/mRNAs in THP-1 macrophages and THP-1 macrophage-derived foam cells, we select some differentially expressed LncRNAs and explore their roles in atherosclerosis process. We already find that some LncRNA can effect cholesterol metabolism and level of infl...

ORGANISM(S): Homo sapiens

2014-05-20 | E-GEOD-54039 | biostudies-arrayexpress

RNA-Seq of Influenza A virus infected THP-1 cells at different timepoint

THP-1 cells were infected by IAV virus strain X31 with a MOI=10, and cells were collected at 3 timepoints:0 hr, 24 hr and 48 hr post-infection. Each timepoint has 3 biological replicates.

ORGANISM(S): Homo sapiens

2025-01-10 | E-MTAB-14283 | biostudies-arrayexpress

Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces

Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...

2020-01-23 | MTBLS721 | MetaboLights

Identification of genes differentially regulated upon infection of Thp-1 cells with H37Rv

Perturbation of host physiology by intracellular Mycobacterium tuberculosis (H37Rv) can be reflected by changes in gene expression pattern of host genes. Total RNA was isolated from PMA differentiated uninfected cells or cells infected with H37Rv for 16, 48 or 90 hours and gene expression profile wa...

ORGANISM(S): Homo sapiens

2010-05-27 | E-GEOD-19052 | biostudies-arrayexpress

Dissecting the Mycobacterium bovis BCG response to macrophage infection to identify targets for anti-tuberculosis drug and vaccine discovery

New strategies are required to reduce the worldwide burden of tuberculosis. Intracellular survival and replication of Mycobacterium tuberculosis after macrophage phagocytosis is a fundamental step in the complex host-pathogen interactions that lead to granuloma formation and disease. Greater underst...

ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2

2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress

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