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TranscriptomicsGene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33500 | biostudies-arrayexpress
TranscriptomicsGene expression profile of DAP12 knockdown THP-1 cells following exposure to phorbol 12-myristate 13-acetate
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33503 | biostudies-arrayexpress
TranscriptomicsRNAseq of differentiation states of primary monocytes and THP-1 cells (from two depositors)
Intensive usage of cancer cell lines as cellular model system in cancer research caused the generation of variant subtypes during the last decades. This study focused on the human leukemic THP-1 cell line as a monocyte model. THP-1 cells from two different depositors were differentiated into variou...
ORGANISM(S): Homo sapiens 
2026-07-24 | E-MTAB-17225 | biostudies-arrayexpress
TranscriptomicsMicroarray of differentiation states of primary monocytes and THP-1 cells (from two depositors)
Intensive usage of cancer cell lines as cellular model system in cancer research caused the generation of variant subtypes during the last decades. This study focused on the human leukemic THP-1 cell line as a monocyte model. THP-1 cells from two different depositors were differentiated into variou...
ORGANISM(S): Homo sapiens 
2026-07-24 | E-MTAB-17224 | biostudies-arrayexpress
TranscriptomicsExpression data from THP-1 cells and THP-1 cells stimulated with PMA
Macrophages play a key role in both innate and adaptive immunity, but our knowledge on the changes in transcription regulation that occurs during their differentiation from monocytes is still limited. In this study, we used a meta-analysis followed by a systems biology approach for the identificatio...
ORGANISM(S): Homo sapiens 
2013-12-28 | E-GEOD-53691 | biostudies-arrayexpress
TranscriptomicsInhibition of EZH2 in THP-1 cells
Macrophages play a key role in both innate and adaptive immunity, but our knowledge on the changes in transcription regulation that occurs during their differentiation from monocytes is still limited. In this study, we used a meta-analysis followed by a systems biology approach for the identificatio...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-71671 | biostudies-arrayexpress
TranscriptomicsRNAseq of primary human monocyte derived macrophages (MDM) and differentiated THP-1 macrophages exposed to graphene-related (nano)materials (GRMs)
Occupational and consumer exposure to GRMs will increase but their impact on human health is still largely unknown. We sought to perform a transcriptome comparison of the bioresponses of MDM and THP-1 macrophages exposed to 5 or 20 µg/ml graphene oxide (GO) or graphene nanoplatelets (GNP) for 6 and ...
ORGANISM(S): Homo sapiens 
2023-02-01 | E-MTAB-10099 | biostudies-arrayexpress
TranscriptomicsTHP-1 human monocytes Transcriptome following exposure to S-nitrosoglutathione (GSNO)
To further study the transcriptome of THP-1 human monocytes after exposure to of S-nitrosoglutathione (GSNO), we investigate whole genome microarray expression to identify genes regulated by exposure to GSNO (1.4 or 6 µM). Changes in gene expression in THP-1 cells incubated without (control) or wit...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69024 | biostudies-arrayexpress
ProteomicsGlycoproteomes of naive and LPS stimulated human monocytes and THP-1 cells
CD14+ Monocytes from healthy volunteers were purified by MACS (negative selection) and FACSorting and either left untreated or stimulated for 24h and 48h with LPS. THP-1 cells were stimulated for 4h, 24h and 48h with LPS. Glycoproteins were captured with hydrazide chemistry and tryptic and PNGase F-...
ORGANISM(S): Homo sapiens (Human) 
2017-04-24 | PXD004034 | Pride
Monocytes glycoproteomics 
TranscriptomicsTranscription profiling of human leukemia cell lines KG-1, U937 and THP-1 vs. normal human blood monocytes
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3280 | biostudies-arrayexpress
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