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ProteomicsMild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation: exploration of platelet proteome and lipidome.
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Trillions of people worldwide display mildly elevated levels of plasma lipids and cholesterol due to diet and life-style. The relationship between severe hyperlipidemia and thrombosis has been extensively investigated, but...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-08 | PXD020276 | Pride
Proteomics Platelet activation Thrombus formation Coagulation Hyperlipidemia Mouse platelets 
TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
GenomicsFavine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway
Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway
PRJNA760442 | ENA
TranscriptomicsFavine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway
Currently, no mouse models manifest calcification and thrombus formation, which is frequently associated with human atherosclerosis. We demonstrated that lack of Favine/CCDC3 in apoE knockout mice accelerated atherosclerosis accompanied by large cholesterol crystals and calcification, and also promo...
ORGANISM(S): Mus musculus 
2022-10-12 | GSE183376 | GEO
UnknownThiol isomerases in thrombus formation.
Not available
S-EPMC4067134 | biostudies-literature
GenomicsDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia
Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia
PRJNA1048405 | ENA
TranscriptomicsDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia
Background: Clinical failure of arteriovenous fistulae (AVF) is frequently due to juxta-anastomotic neointimal hyperplasia (JANIH). Although the mouse AVF model recapitulates human AVF maturation, previous studies focused on the outflow vein distal to the anastomosis. We hypothesized that the juxta-...
ORGANISM(S): Mus musculus 
2023-12-08 | GSE249267 | GEO
UnknownDNAse-dependent, NET-independent pathway of thrombus formation in vivo.
Not available
S-EPMC8285961 | biostudies-literature
UnknownQuantification of Platelet Contractile Movements during Thrombus Formation.
Not available
S-EPMC6298232 | biostudies-literature
UnknownGlycoprotein VI-dependent and -independent pathways of thrombus formation in vivo.
Not available
S-EPMC1895285 | biostudies-literature
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