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Unknown18F-FDG and 68 Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models.

Purpose

We built a joint replacement loosening model based on the original rabbit model of infection and evaluated the performance characteristics of 18F-FDG and 68 Ga-FAPI in evaluating infection and loosening.

Methods

After surgery, the rabbits were divided int...
S-EPMC9208226 | biostudies-literature
UnknownΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82.
ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer stem cell properties in squamous cell carcinoma. However, with regards to the p...
S-EPMC5543260 | biostudies-literature
UnknownCarm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Here, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly accelerates BMT helped to illuminate the mechanism. Thus, incoming C/EB...
S-EPMC10299824 | biostudies-literature
UnknownClaudin 18.2 expression in gastroesophageal adenocarcinoma: biomarker overlap and association with clinical outcomes in a European cohort.

Background

Claudin 18.2 (CLDN18.2) is highly expressed in up to 40% of gastroesophageal adenocarcinomas (GEA) and represents an emerging therapeutic target for these tumors. However, its distribution across molecular subtypes and its prognostic and predictive roles remain insufficiently stud...
S-EPMC12865641 | biostudies-literature
UnknownHuman Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation.

Purpose

Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1, and BRCA1/2 have been identified...
S-EPMC9873249 | biostudies-literature
UnknownRole of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential.

Background and objective

Cholangiocarcinoma (CCA) is a heterogeneous neoplasm of the biliary epithelium that easily infiltrates, metastasises and recurs. Magnesium disbalance is a hallmark of CCA, with the magnesium transporter cyclin M4 (CNNM4) being a key driver of various hepatic diseases...
S-EPMC12911659 | biostudies-literature
UnknownA Multi-Organ Nucleus Segmentation Challenge.
Generalized nucleus segmentation techniques can contribute greatly to reducing the time to develop and validate visual biomarkers for new digital pathology datasets. We summarize the results of MoNuSeg 2018 Challenge whose objective was to develop generalizable nuclei segmentation techniques in digi...
S-EPMC10439521 | biostudies-literature
UnknownA model for presenting accelerometer paradata in large studies: ISCOLE.

Background

We present a model for reporting accelerometer paradata (process-related data produced from survey administration) collected in the International Study of Childhood Obesity Lifestyle and the Environment (ISCOLE), a multi-national investigation of >7000 children (averaging 10.5 yea...
S-EPMC4409714 | biostudies-literature
UnknownExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

Aims/hypothesis

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenotypes.

Methods

The study comprised th...
S-EPMC3536959 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies.
Not available
S-EPMC9165548 | biostudies-literature
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