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TranscriptomicsExpression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB
Comparison of transcriptional profiles of human umbilical vein endothelial cells (HUVECs) expressing wild-type vs. VM-causative mutant forms of TIE2/TEK. The effects of the most common Venous Malformation-causative mutations in the endothelial cell tyrosine kinase receptor: R849W and L914F, were tes...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-46684 | biostudies-arrayexpress
TranscriptomicsTie2+ vs Tie2- macrophages bulk RNAseq
BulkRNAseq to identify Tie2+ macrophages signature. Cells were sorted for CD14+ and Tie2 (PTEK). Two fractions were hence sequenced on NextSeq platform (Illumina) after full length cDNA amplification using the SMART-Seq mRNA LP kit (Takara).
ORGANISM(S): Homo sapiens 
2026-03-31 | E-MTAB-15962 | biostudies-arrayexpress
GenomicsTie2+ vs Tie2- macrophages bulk RNAseq
Tie2+ vs Tie2- macrophages bulk RNAseq
PRJEB103104 | ENA
ProteomicsIdentification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication
Psoriasis is a chronic inflammatory disease characterized by hyperproliferation of keratinocytes and abnormal blood vessels. As hyperproliferation is driven by pro-inflammatory cytokines produced by activated immune cells, therapeutic strategies often target these cytokines to manage the disease. Ho...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD058810 | Pride
Human oxidation eclipse 
TranscriptomicsGene expression profiles of TIE2 expressing Monocytes (TEMs)
To identify the gene expressing profiles of TIE2 expressing Monocytes(TEMs), we have employed the Agilent lncRNA Gene Expression 4×180K(Design ID:042818) microarray. Human peripheral blood mononuclear cells (PBMCs) in venous blood from healthy donors were isolated by Lymphoprep (Axis-Shield, Norwa...
ORGANISM(S): Homo sapiens 
2017-05-17 | E-GEOD-57783 | biostudies-arrayexpress
GenomicsRNA-sequencing of Endothelial Cell Lines Expressing TIE2 WT or Mutant TIE2-L914F
RNA-sequencing of Endothelial Cell Lines Expressing TIE2 WT or Mutant TIE2-L914F
PRJNA1320648 | ENA
TranscriptomicsMesp1 induces a subset of hematopoietic-associated transcription factors in ES cell-derived Flk1+Tie2+ endothelium
Previously, we reported that the transcription factor Mesp1 promotes the cell fates of cardiomyocytes, smooth muscle, and vascular endothelium. Recently, hematopoietic stem cells (HSCs) were shown to derive from hemogenic endothelium. Since Mesp1 regulates development of endothelium, it potentially...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-34537 | biostudies-arrayexpress
TranscriptomicsROSA26Foxf1; Tie2-cre lung gene expression analysis.
Analysis of genes deregulated due to heterozygous overexpression of Foxf1 in endothelial and hematopoietic cells using Tie2-cre in embryonic day 18.5 mouse lungs. Total RNA obtained from three ROSA26Foxf1; Tie2-cre mouse lungs compared to three control ROSA26-lox-stop-lox (LSL) -Foxf1 mouse lungs.
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-77881 | biostudies-arrayexpress
GenomicsTIE2 mutations in VM
Venous Malformation: from causative TIE2 mutations to murine model and targeted therapy
PRJEB9698 | ENA
GenomicsTie2 regulates endocardial sprouting and myocardial trabeculation
Tie2 regulates endocardial sprouting and myocardial trabeculation
PRJNA541264 | ENA
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