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TranscriptomicsThe Co-inhibitory Receptor TIGIT has T cell intrinsic functions
We compared the gene expression in wild type CD4+ T cells stimulated with agonistic anti-TIGIT 4D4 antibody to that of isotype and TIGIT-deficient (KO) controls.
ORGANISM(S): Mus musculus 
2011-01-01 | E-MEXP-2847 | biostudies-arrayexpress
ProteomicsInhibitory TIGIT signalling is dependent on activating T cell receptor signalling
TIGIT is an immune checkpoint receptor that can signal via its intracellular inhibitory motifs to inhibit T cells, though the mechanisms remain poorly defined. To elucidate inhibitory signalling interactors of TIGIT, proximity proteomics was employed in model Jurkat T cells expressing TIGIT fused to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD063349 | Pride
Proximity proteomics Apex2 Signalling T cells Tigit 
TranscriptomicsscRNA- and TCR-Seq of mouse T cells from WT and TIGIT KO mice at steady state and upon LCMV infection
The experimental setup is aimed at understanding the function of the co-inhibitory receptor TIGIT in T cells. We compared sorted T cells (CD8+ T cells, CD4+Foxp3- T cells, CD4+Foxp3+ Tregs) from WT and TIGIT KO mice at steady state (naive mice) and following LCMV infection (day 10, LCMV clone 13). C...
ORGANISM(S): Mus musculus 
2025-09-14 | E-MTAB-14959 | biostudies-arrayexpress
TranscriptomicsTIGIT+ Tregs
TIGIT+ Tregs suppress Th1 and Th17 responses while sparing Th2 responses. Analysis of global gene expression of TIGIT+ vs. TIGIT- Tregs from naive mice reveled that TIGIT+ Tregs display an activated phenotype and are enriched for Treg signature genes including the Treg effector molecule Fgl2 which e...
ORGANISM(S): Mus musculus 
2014-12-12 | E-GEOD-56299 | biostudies-arrayexpress
GenomicsEffect of Tigit deficiency on CD4 T cell
Effect of Tigit deficiency on CD4 T cell
PRJNA1147618 | ENA
TranscriptomicsTIGIT+ Tregs
TIGIT+ Tregs suppress Th1 and Th17 responses while sparing Th2 responses. Analysis of global gene expression of TIGIT+ vs. TIGIT- Tregs from naive mice reveled that TIGIT+ Tregs display an activated phenotype and are enriched for Treg signature genes including the Treg effector molecule Fgl2 which e...
ORGANISM(S): Mus musculus 
2014-12-12 | GSE56299 | GEO
GenomicsTIGIT expression on CD8+ T cells correlates with higher cytotoxic capacity
TIGIT expression on CD8+ T cells correlates with higher cytotoxic capacity
PRJNA718607 | ENA
GenomicsActivation-induced cell death of ILC2s via TIGIT suppresses chronic airway allergy
Activation-induced cell death of ILC2s via TIGIT suppresses chronic airway allergy
PRJNA874421 | ENA
GenomicsTIGIT Blockade Exerts Synergistic Effects on Microwave Ablation against Cancer
TIGIT Blockade Exerts Synergistic Effects on Microwave Ablation against Cancer
PRJNA799733 | ENA
GenomicsImplication of TIGIT+ human memory B cells in immune regulation
Implication of TIGIT+ human memory B cells in immune regulation
PRJNA635792 | ENA
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