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ProteomicsTargeting the NPY/NPY1R Signaling Axis in Mutant p53-Dependent Pancreatic Cancer Impairs Metastasis
Pancreatic Cancer (PC) is a highly metastatic malignancy. Over 80% of PC patients present with advanced-stage disease, preventing potentially curative surgery. The Neuropeptide Y (NPY)system, best known for its role in controling energy homeostasis, has also been show to promote tumorigenesis in a r...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058833 | Pride
Pancreatic cancer Neuropeptide y 
ProteomicsRal GTPases promote metastasis by controlling biogenesis and organotropism of exosomes
Cancer extracellular vesicles (EVs) mainly exert pro-tumoral functions by changing the phenotypes of stromal cells to the benefit of tumor growth and metastasis. In particular, they shuttle to distant organs and seed pre-metastatic niches facilitating subsequent colonization by circulating tumor cel...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020180 | Pride
Human Ral Nanolcmsms prostar maxquant Extracellular vesicles 
ProteomicsTemporal Profiling of PyMT Tumour Matrisome during Progression
In this study, through coupling of our ISDoT tissue decellularisation technology with quantitative mass spectrometry, we explored the changing tumour matrisome during mammary tumourigenesis in the PyMT breast cancer model compared to age-matched healthy control mammary gland
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-03-30 | MSV000089167 | MassIVE
UnknownChildhood intelligence is heritable, highly polygenic and associated with FNBP1L.
Not available
S-EPMC3935975 | biostudies-literature
UnknownRal GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.
Not available
S-EPMC7822591 | biostudies-literature
UnknownVariants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Not available
S-EPMC2862164 | biostudies-literature
UnknownHigh-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response.
Not available
S-EPMC11108778 | biostudies-literature
UnknownLoci for insulin processing and secretion provide insight into type 2 diabetes risk.
Not available
S-EPMC9943750 | biostudies-literature
UnknownDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Not available
S-EPMC7610439 | biostudies-literature
UnknownDirectional dominance on stature and cognition in diverse human populations.
Not available
S-EPMC4516141 | biostudies-literature
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