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ProteomicsInhibition of KDEL receptors remodels the tumor microenvironment for T cell independent tumor regression
Tumor immunotherapy is supported by low-grade inflammatory conditions at the microenvironment, triggered by immunogenic cell death (ICD). However, ICD is dampened when tumors acquire resistance, affecting immune recognition. KDEL receptors (KDELRs), through a retrograde Golgi-to-ER transport, preven...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD072994 | Pride
Kdel protein Er stress Tumor microenvironment 
ProteomicsPharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
We analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to sin...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD014709 | Pride
Lc-ms Human Plasma membrane 
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