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ModelsNeiburga2022 - Arabidopsis thaliana wild-type MEP pathway kinetic model
Kinetic model of extended MEP pathway in wild-type Arabidopsis thaliana. This model was used for the Parameter Estimation task in COPASI. Reactions for isoprene and cis-abienol synthesis are included but made inactive by setting their k=0. A new Parameter Estimation task can be performed by accesin...
2023-02-04 | MODEL2206090001 | BioModels
ModelsNeiburga2022 - Arabidopsis thaliana MEP pathway with cis-abienol synthesis
Kinetic model of extended MEP pathway in Arabidopsis thaliana for cis-abienol production. This model was used for determining total optimization potential (TOP) of cis-abienol production in Arabidopsis thaliana using Spacescanner (https://github.com/atiselsts/spacescanner). This model was used to m...
2023-02-04 | MODEL2206090002 | BioModels
TranscriptomicsMultiomics of tomato glandular trichomes reveals distinct features of central carbon metabolism supporting high productivity of specialized metabolites
Glandular trichomes (GT) are specialized cell factories that have the capacity to produce large amounts of metabolites which can amount to over 10% of the leaf dry weight. The specific expression of secondary metabolite pathways in glandular trichomes has facilitated their elucidation. However, litt...
ORGANISM(S): Solanum lycopersicum 
2017-05-31 | E-MTAB-4482 | biostudies-arrayexpress
ModelsNeiburga2022 - Arabidopsis thaliana MEP pathway with isoprene synthesis
Kinetic model of extended MEP pathway in Arabidopsis thaliana for isoprene. This model was used for determining total optimization potential (TOP) of isoprene production in Arabidopsis thaliana using Spacescanner (https://github.com/atiselsts/spacescanner). This model was used to make designs D, E ...
2023-02-04 | MODEL2206090003 | BioModels
MetabolomicsThe Arabidopsis Concert of Metabolic Acclimation to High Light Stress

In plants, exposure to high light irradiation induces various stress responses, which entail complex metabolic rearrangements. To explore these dynamics, we conducted time-course experiments spanning 2 minutes to 72 hours with Arabidopsis thaliana under high and control light. Comparative metabol...

2024-08-16 | MTBLS3109 | MetaboLights
MetabolomicsMultiomics of tomato glandular trichomes reveals distinct features of central carbon metabolism supporting high productivity of specialized metabolites
Glandular trichomes are metabolic cell factories with the capacity to produce large quantities of secondary metabolites. Little is known about the connection between central carbon metabolism and metabolic productivity for secondary metabolites in glandular trichomes. To address this gap in our know...
2017-04-25 | MTBLS297 | MetaboLights
ProteomicsArabidopsis high light redox proteomics
DDA experiment investigating differential cystein redox modification using iodoTMT label on high light treated samples from Arabidsopsis thaliana leaves.
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-08-23 | PXD048299 | JPOST Repository
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
MetabolomicsAn Evolutionarily Conserved Metabolite Inhibits Biofilm Formation in Escherichia coli K-12
Methylerythritol cyclodiphosphate (MEcPP) is an intermediate in the biosynthesis of isoprenoids in plant plastids and in bacteria, and acts as a stress signal in plants. Here, we show that MEcPP regulates biofilm formation in Escherichia coli K-12 MG1655. Increased MEcPP levels, triggered by genetic...
2024-11-01 | MTBLS2240 | MetaboLights
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
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