Sort   by:  
 Page size 
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
MetabolomicsUnique metabolic regulation of micromeres contributes to their inductive signaling in the sea urchin embryo

In many multicellular organisms, a group of cells called organizers plays critical roles by sending signals to adjacent cells and controlling patterning events such as embryogenesis and tissue morphogenesis. Recent studies suggest that these organizers or inductive cells facilitate the downstream...

2025-07-07 | MTBLS5017 | MetaboLights
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
GenomicsThe RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner
Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in different species implicates RNA and RNA-binding proteins as regulators of chromatin insulator activ...
ORGANISM(S): Drosophila melanogaster 
2014-04-18 | E-GEOD-51462 | biostudies-arrayexpress
MetabolomicsA metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans
Caenorhabditis elegans provides a genetically tractable model organism to investigate the network of genes involved in fat metabolism and how regulation is perturbed to produce the complex phenotype of obesity. C. elegans possess the full range of desaturases, including the delta-9 desaturases expre...
2012-02-14 | MTBLS3 | MetaboLights
TranscriptomicsTissue-specific genetic regulation of splicing and expression (gene-level)
Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression and splicing remains unclear. We carried out the first genome-wide scre...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-30453 | biostudies-arrayexpress
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
Sort   by:  
 Page size